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gentianine

from Gentiana macrophylla

Also Known As:

5-ethenyl-3,4-dihydro-1H-pyrano(3,4-c)pyridin-1-one

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - gentianine: 4

Experts

1.	Chen, Jianxin: 1 article (11/2021)
2.	Gao, Chengwen: 1 article (11/2021)
3.	Jia, Caixia: 1 article (11/2021)
4.	Li, Zhiqiang: 1 article (11/2021)
5.	Liu, Yao: 1 article (11/2021)
6.	Wang, Na: 1 article (11/2021)
7.	Wu, Chuanhong: 1 article (11/2021)
8.	Wu, Mingxuan: 1 article (11/2021)
9.	Zhang, Qian: 1 article (11/2021)
10.	Zhao, Xiangzhong: 1 article (11/2021)

Related Diseases

1.	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 11/01/2021 - "In this study, the effect of Gentianine on transient middle cerebral artery occlusion (tMCAO) induced mouse model in vivo and further related mechanism in LPS-injuried microglia BV-2 cells in vitro were explored. "
2.	Brain Infarction 11/01/2021 - "Effect of Gentianine on tMCAO mouse demonstrated that Gentianine significantly ameliorated tMCAO induced ischemic injury by decreasing brain infarct volume and increasing the neurological score and upper limb muscle strength. "
3.	Inflammation (Inflammations) 11/01/2021 - "Gentianine, an alkaloid isolated from Gentiana Scabra Bunge, shows effectiveness in anti-inflammation. "
4.	Hypersensitivity (Allergy) 01/01/2012 - "These plants compounds were selected because; parts of these plants are widely used againsts inflamation, allergy, asthma etc. Three metabolites of Swertia chirata namely Gentianine (GENT), Xanthone (XANT) and Swerchirin (SWER) are found to be occupying the same binding pocket in the LBD of the GR (PDB ID 1M2Z). "
5.	Ulcerative Colitis 11/16/2023 - "Gentianine alleviates dextran sulfate sodium-induced ulcerative colitis via inhibition of TLR4/NLRP3-mediated pyroptosis."

Related Drugs and Biologics

1.	Dextran Sulfate
2.	Alkaloids
3.	swerchirin
4.	xanthone