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LY 150310
structure given in first source; RN given refers to parent cpd
Also Known As:
LY 150310 mono-NO4; LY-150310; LY150310
Networked:
2
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Azoles: 2138
Imidazoles: 150
LY 150310: 2
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Polycyclic Aromatic Hydrocarbons: 2020
Naphthalenes: 18
Tetrahydronaphthalenes: 1
LY 150310: 2
Polycyclic Compounds: 6
Polycyclic Aromatic Hydrocarbons: 2020
Naphthalenes: 18
Tetrahydronaphthalenes: 1
LY 150310: 2
Related Diseases
1.
Bronchial Spasm
11/01/1993 - "
In other studies, in which postmortem pulmonary gas trapping was used as an index of in vivo airway obstruction, i.v. LY150310 dose-dependently inhibited the bronchospasm produced by aerosols of the divalent cationic ionophore A23187, histamine, 5-hydroxytryptamine, leukotriene D4, methacholine, ovalbumin or platelet activating factor.
"
2.
Airway Obstruction (Choking)
11/01/1993 - "
Also, orally administered LY150310 inhibited the airway obstruction produced by selected challenge aerosols.
"
11/01/1993 - "
Our results demonstrate that LY150310 reduces airway obstruction caused by a variety of bronchoconstrictive agents, including A23187 and ovalbumin.
"
11/01/1993 - "
However, PGE2 and other cyclooxygenase products did not appear to account for in vivo bronchodilation, because combining LY150310 and piroxicam did not alter inhibition of A23187-induced airway obstruction.
"
11/01/1993 - "
In other studies, in which postmortem pulmonary gas trapping was used as an index of in vivo airway obstruction, i.v. LY150310 dose-dependently inhibited the bronchospasm produced by aerosols of the divalent cationic ionophore A23187, histamine, 5-hydroxytryptamine, leukotriene D4, methacholine, ovalbumin or platelet activating factor.
"
3.
Neoplasm Metastasis (Metastasis)
08/15/1989 - "
The abilities of the Eli Lilly compounds LY150310, LY189332, and LY135305 to inhibit spontaneous metastasis and to increase animal survival were evaluated.
"
08/15/1989 - "
Nafazatrom, LY150310, LY189332, and LY135305 were found to inhibit spontaneous lung metastasis in a dose-dependent manner.
"
Related Drugs and Biologics
1.
Leukotriene D4
2.
Methacholine Chloride (Methacholine)
3.
Serotonin (5 Hydroxytryptamine)
4.
Platelet Activating Factor
5.
Ovalbumin
6.
Ionophores
7.
Histamine (Histamine Dihydrochloride)
8.
Aerosols
9.
Calcimycin (A23187)
10.
Dinoprostone (PGE2)