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lacidipine

Also Known As:

Boehringer Ingelheim Brand of Lacidipine; Caldine; GR 43659X; GR-43659X; GlaxoSmithKline Brand of Lacidipine; Lacimen; Lacipil; Menarini Brand of Lacidipine; Motens; diethyl 2,6-dimethyl-4-(2-((E)-2-((2-methylpropan-2-yl)oxycarbonyl)ethenyl)phenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Networked: 196 relevant articles (23 outcomes, 80 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 60
- 1-Ring Heterocyclic Compounds
  - Pyridines: 41
    - Dihydropyridines: 177
      - lacidipine: 196

Experts

1.	Mancia, Giuseppe: 13 articles (12/2014 - 11/2002)
2.	Zanchetti, Alberto: 13 articles (12/2014 - 11/2002)
3.	Hennig, Michael: 8 articles (09/2009 - 11/2002)
4.	Parati, Gianfranco: 6 articles (12/2014 - 05/2005)
5.	Frostegård, Johan: 6 articles (01/2014 - 09/2002)
6.	Tang, Rong: 6 articles (09/2009 - 06/2004)
7.	de Faire, Ulf: 5 articles (01/2014 - 09/2003)
8.	Halici, Zekai: 5 articles (06/2012 - 09/2006)
9.	Facchetti, Rita: 4 articles (12/2014 - 09/2009)
10.	Suleyman, Halis: 4 articles (11/2012 - 09/2006)

Related Diseases

1.	Hypertension (High Blood Pressure) 12/01/2014 - "Because lacidipine appears to have no effect on CsA exposure, it may be the best option among CCBs for treating high blood pressure caused by CsA in children." 07/01/1999 - "These data suggest that lacidipine is effective in reversing hypertension and reducing target organ damage induced by HFD. " 01/01/1994 - "Therefore, lacidipine can be considered a safe antihypertensive drug, which can be used as a suitable agent for first-line treatment of hypertension." 01/01/1995 - "In conclusion, lacidipine possesses vascular selectivity and its effect in essential hypertension is characterized by vasodilation and by the maintenance, or even improvement, in vital organ perfusion." 01/01/1991 - "Furthermore, as it has the advantages of a long duration of action and once-daily dosage, the benefit/risk ratio indicates that lacidipine is a suitable agent for the first-line treatment of hypertension across a wide range of patients."
2.	Edema 08/01/1994 - "Clinical studies suggest that lacidipine (LA) is better tolerated than other DHP, in terms of peripheral edema. " 08/01/1994 - "Our results confirm, in SHR, that lacidipine induces a very moderate edema formation. " 01/01/2000 - "All studies suggesting a lower incidence of edema on lacidipine than on amlodipine are based on subjective scoring. " 01/01/2000 - "In conclusion, our data show a higher incidence of edema on amlodipine than on lacidipine, which has to be explained at least partly by a comparably higher dose c.q. " 01/01/2000 - "Edema, scored visually, occurred more frequently (p = 0.02) on amlodipine (15/32) than on lacidipine (6/30); this was confirmed by an increase of foot volume above the 95% upper limit of normal variation in 15 patients on amlodipine and in only five patients on lacidipine (p = 0.01). "
3.	Type 2 Diabetes Mellitus (MODY) 12/01/2010 - "The aim of this study was to evaluate the efficacy of lacidipine in reducing blood pressure (BP) and to determine its effect on endothelial function in mild-to-moderate hypertensive patients with type 2 diabetes mellitus (DM). " 01/01/2003 - "Lacidipine was effective in elderly patients (including those with isolated systolic hypertension), African Nigerian patients and patients with concurrent type 2 diabetes mellitus. " 03/01/1999 - "The drug had no effect on the increased urinary excretion of the stable metabolic products of NO. These data suggest that lacidipine might be useful in preventing the renal and cardiac damage caused by hypertension and non-insulin-dependent diabetes mellitus." 01/01/1994 - "Antihypertensive and metabolic effects of lacidipine in patients with NIDDM and/or hypertension." 05/01/1999 - "Effect of chronic treatment with lacidipine or lisinopril on intracellular partitioning of glucose metabolism in type 2 diabetes mellitus."
4.	Atherosclerosis 06/01/2005 - "In the European Lacidipine Study on Atherosclerosis (ELSA), against a similar antihypertensive effect, a significantly greater effect of lacidipine was found on carotid intima-media thickness (IMT) progression, indicating a specific anti-atherosclerotic effect of lacidipine. " 06/01/2012 - "Visit-to-visit blood pressure variability in the European Lacidipine Study on Atherosclerosis: methodological aspects and effects of antihypertensive treatment." 01/01/2012 - "Serum levels and binding specificities of different anti-PC isotypes were determined in 226 hypertensive individuals enrolled in European Lacidipine Study on Atherosclerosis using ELISA. " 09/22/2009 - "Analyses were performed of the data from the European Lacidipine Study on Atherosclerosis (ELSA), a large, randomized, intervention trial in which 2334 hypertensive patients from 7 European countries were followed up under effective antihypertensive treatment for 3.75 years. " 09/22/2009 - "Baseline values but not treatment-induced changes in carotid intima-media thickness predict incident cardiovascular events in treated hypertensive patients: findings in the European Lacidipine Study on Atherosclerosis (ELSA)."
5.	Inflammation 06/08/2005 - "Lacidipine leads to a significant reduction of the common carotid artery IMT as well as to a decrease in markers of inflammation in patients with CAD during a relatively short period (6 months)." 11/01/2012 - "The interstitial inflammation of the kidneys in the lacidipine group was higher than that of the other treatment groups. " 09/01/2006 - "Effects of amlodipine, lacidipine and nicardipine on acute phase of inflammation in the carregeenan model in intact rats were investigated in this study. " 09/01/2006 - "Amlodipine at 5 and 10 mg/kg doses showed 61%, 80%, lacidipine 73%, 34% and nicardipine 38%, 87% inhibition of carrageenan-induced inflammation, respectively. "

Related Drugs and Biologics

1.	1,4-dihydropyridine (dihydropyridine)
2.	lercanidipine
3.	Felodipine (Agon)
4.	Atenolol (Tenormin)
5.	Amlodipine (Norvasc)
6.	Hydrochlorothiazide (Esidrix)
7.	Nifedipine (Adalat)
8.	Nicardipine (Dagan)
9.	Chlorthalidone (Chlortalidone)
10.	Calcium Channels (Calcium Channel)

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