potassium channel protein I(sk)

a K+ channel or an integral constituent of it; induces selective potassium permeation by membrane depolarization; 130 amino acid residues; isolated from rat, mouse & humans; amino acid sequence (human) in first source

Also Known As:

Networked: 15 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Kass, Robert S: 4 articles (02/2012 - 01/2002)
2.	Sampson, Kevin J: 3 articles (02/2012 - 01/2008)
3.	Marx, Steven O: 2 articles (02/2012 - 01/2002)
4.	Osteen, Jeremiah D: 2 articles (02/2012 - 12/2011)
5.	Terrenoire, Cecile: 2 articles (12/2011 - 01/2008)
6.	Eldstrom, Jodene: 1 article (01/2020)
7.	Fedida, David: 1 article (01/2020)
8.	Wang, Yundi: 1 article (01/2020)
9.	Harmer, Stephen C: 1 article (05/2012)
10.	Kemp, Duncan: 1 article (05/2012)

Related Diseases

1.	Atrial Fibrillation 02/06/2007 - "This study sought to evaluate mutations in genes encoding the slow component of the cardiac delayed rectifier K+ current (I(Ks)) channel in familial atrial fibrillation (AF). " 02/01/2012 - "These results further our understanding of the structural relationship between KCNE1 and KCNQ1 subunits in the I(Ks) channel, and provide mechanisms for understanding the effects on channel deactivation underlying these two atrial fibrillation mutations." 01/15/2008 - "Inherited gain-of-function mutations of genes coding for subunits of the heart slow potassium (I Ks) channel can cause familial atrial fibrillation (AF). "
2.	Cardiac Arrhythmias (Arrythmia) 02/01/2012 - "Inherited mutations in either I(Ks) channel subunit are associated with cardiac arrhythmia syndromes. " 01/15/2008 - "Our results provide evidence that beta-AR-regulated I Ks channels can play a role in AF and imply that specific I Ks deregulation, perhaps through disruption of the I Ks macromolecular complex necessary for beta-AR-mediated I Ks channel regulation, may be a novel therapeutic strategy for treating this most common arrhythmia." 10/01/2003 - "The strategies to find potent and selective I(Ks) channel will be reviewed as well as their first results in in-vitro and in-vivo models of arrhythmia. " 01/18/2002 - "Mutations in two human I(KS) channel subunits, hKCNQ1 and hKCNE1, prolong APD and cause inherited cardiac arrhythmias known as LQTS (long QT syndrome). " 01/01/2020 - "Given that mefenamic acid can enhance all I Ks channel complexes containing different ratios of KCNQ1 to KCNE1, it may provide a promising therapeutic approach to treating life-threatening cardiac arrhythmia syndromes. "
3.	Long QT Syndrome 12/15/2011 - "Because mutations in the gene for the I(Ks) α subunit, KCNQ1, constitute the majority of long QT syndrome (LQT-1) cases, we have carried out a detailed biophysical analysis of this channel expressed in hESCs to establish baseline I(Ks) channel biophysical properties in cardiac myocytes derived from hESCs (hESC-CMs). " 01/18/2002 - "Mutations in two human I(KS) channel subunits, hKCNQ1 and hKCNE1, prolong APD and cause inherited cardiac arrhythmias known as LQTS (long QT syndrome). " 01/01/2023 - "Long QT syndrome-associated calmodulin variants disrupt the activity of the slowly activating delayed rectifier potassium channel." 12/05/2008 - "Mutations in I(Ks) channel alpha (KCNQ1, KvLQT1, Kv7.1) or beta (KCNE1, IsK, minK) subunits cause long QT syndrome (LQTS), an inherited cardiac arrhythmia associated with increased risk of sudden death. " 12/10/2004 - "The KCNQ1-G589D gene mutation, associated with a long-QT syndrome, has been shown to disrupt yotiao-mediated targeting of protein kinase A and protein phosphatase-1 to the I(Ks) channel. "
4.	Hearing Loss (Hearing Impairment) 01/01/2001 - "Genetic null deletion of the I(Ks) channel in mice and man results in profound hearing loss and cochlear pathology. "
5.	Romano-Ward Syndrome 05/01/2012 - "The nonsense mutations R518X-KCNQ1 and Q530X-KCNQ1 cause LQT1 (long-QT syndrome type 1) and result in a complete loss of I(Ks) channel function. "

Related Drugs and Biologics

1.	Potassium
2.	Protein Phosphatase 1
3.	Adrenergic Agents (Adrenergic Drugs)
4.	Nonsense Codon (Nonsense Mutation)
5.	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)
6.	Mefenamic Acid (Pontal)
7.	Calmodulin (Calcium-Dependent Activator Protein)