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mycalamide A

structure given in first source; RN given refers to (2R-(2alpha,2(S*(S*)),5beta,6beta))-isomer; isolated from marine sponges

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - mycalamide A: 2

Experts

1.	Bokemeyer, Carsten: 1 article (06/2012)
2.	Dyshlovoy, Sergey A: 1 article (06/2012)
3.	Fedorov, Sergey N: 1 article (06/2012)
4.	Honecker, Friedemann: 1 article (06/2012)
5.	Kalinovsky, Anatoly I: 1 article (06/2012)
6.	Shubina, Larisa K: 1 article (06/2012)
7.	Stonik, Valentin A: 1 article (06/2012)

Related Diseases

1.	Neoplasms (Cancer) 06/01/2012 - "Here, for the first time, we report the isolation of mycalamide A from ascidian Polysincraton sp. as well as investigation of its cancer preventive properties. " 06/01/1989 - "Mycalamide-A and -B were also potent inhibitors of HL-60, HT-29, and A549 human tumor cell replication (50% inhibitory concentration less than 5 nM), while values for onnamide were greater (50% inhibitory concentrations between 25 and 200 nM). " 06/01/1989 - "Mycalamide-A was also active against B16 melanoma, Lewis lung carcinoma, M5076 ovarian sarcoma, colon 26 carcinoma, and the human MX-1, CX-1, and Burkitt's lymphoma tumor xenografts. "
2.	Lewis Lung Carcinoma 06/01/1989 - "Mycalamide-A was also active against B16 melanoma, Lewis lung carcinoma, M5076 ovarian sarcoma, colon 26 carcinoma, and the human MX-1, CX-1, and Burkitt's lymphoma tumor xenografts. "
3.	Sarcoma (Soft Tissue Sarcoma) 06/01/1989 - "Mycalamide-A was also active against B16 melanoma, Lewis lung carcinoma, M5076 ovarian sarcoma, colon 26 carcinoma, and the human MX-1, CX-1, and Burkitt's lymphoma tumor xenografts. "
4.	Experimental Melanoma 06/01/1989 - "Mycalamide-A was also active against B16 melanoma, Lewis lung carcinoma, M5076 ovarian sarcoma, colon 26 carcinoma, and the human MX-1, CX-1, and Burkitt's lymphoma tumor xenografts. "
5.	Leukemia P388 06/01/1989 - "Mycalamide-A (10 micrograms/kg) and -B (2.5 micrograms/kg) were moderately active against P388 leukemia (increase in life span, approximately 50%), while onnamide was inactive (40 micrograms/kg; increase in life span, 15%). "

Related Drugs and Biologics

1.	onnamide