Histocompatibility Antigens Class I

Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during GRAFT REJECTION and restrict cell-mediated lysis of virus-infected cells.

Also Known As:

Class I Histocompatibility Antigens; Class I Human Antigens; Class I MHC Proteins; Class I Major Histocompatibility Antigens; Class I Major Histocompatibility Molecules; Human Class I Antigens; MHC Class I Molecules; MHC-I Molecules; MHC-I Peptides; Antigen, Class I; Antigens, Class I; I Antigen, Class; MHC I Molecules; MHC I Peptide; MHC I Peptides; Molecules, MHC-I; Peptide, MHC-I; Peptides, MHC-I; Class I Antigen; Class I Antigens; Class I Histocompatibility Antigen; Class I MHC Protein; Class I Major Histocompatibility Antigen; MHC Class I Molecule; MHC-I Peptide

Carbohydrates: 22023
- Glycoconjugates: 1353
  - Glycoproteins: 24834
    - Membrane Glycoproteins: 2252
      - Histocompatibility Antigens Class I: 1944
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Glycoproteins: 24834
    - Membrane Glycoproteins: 2252
      - Histocompatibility Antigens Class I: 1944
  - Membrane Proteins: 10078
    - Membrane Glycoproteins: 2252
      - Histocompatibility Antigens Class I: 1944
Biological Factors: 2472
- Antigens: 143924
  - Surface Antigens: 5813
    - Histocompatibility Antigens: 1132
      - Histocompatibility Antigens Class I: 1944
  - Isoantigens: 1221
    - Histocompatibility Antigens: 1132
      - Histocompatibility Antigens Class I: 1944

1.	T-Cell Lymphoma (Lymphoma, T Cell) 05/15/1989 - "In a comparative approach to the evolution of the MHC, we isolated eight molecular clones of feline MHC (termed FLA for feline leukocyte antigen) class I genes from a cDNA library of a cat T cell lymphoma line. "

feline leukocyte antigen

Bio-Agent Context: Research Results

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