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deltorphin

isolated from skin of Phyllomedusa sauvagei; has affinity to opioid receptor; note deltorphin I and deltorphin II are available, they have Ala in position 2
Also Known As:
Tyr-Met-Phe-His-Leu-Met-Asp-NH2; dermenkephalin; tyrosyl-methionyl-phenylalanyl-histidyl-leucyl-methionyl-aspartamide
Networked: 25 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Oeltgen, Peter R: 4 articles (01/2014 - 02/2006)
2. Govindaswami, Meera: 3 articles (03/2008 - 02/2006)
3. Oeltgen, Peter: 3 articles (01/2008 - 05/2004)
4. Barzakh, Eva I: 2 articles (01/2014 - 11/2010)
5. Brown, Stephen A: 2 articles (01/2014 - 11/2010)
6. Krylatov, Andrey V: 2 articles (01/2014 - 11/2010)
7. Lishmanov, Yury B: 2 articles (01/2014 - 11/2010)
8. Maslov, Leonid N: 2 articles (01/2014 - 11/2010)
9. Pei, Jian-Ming: 2 articles (01/2014 - 11/2010)
10. Capasso, Anna: 2 articles (03/2009 - 02/2002)

Related Diseases

1. Hypoglycemia (Reactive Hypoglycemia)
2. Wounds and Injuries (Trauma)
3. Hyperphagia (Overeating)
4. Ischemia
03/01/2008 - "The authors present evidence that the delta opioid receptor agonist Deltorphin-D(variant) (Delt-D(var)) and hibernating woodchuck plasma (HWP), but not summer-active woodchuck plasma (SAWP), can provide significant neuroprotection from focal ischemia in mice by a mechanism that relies in part on reducing nitric oxide (NO) release in ischemic tissue. "
11/01/2005 - "In contrast, the pretreatment with the selective delta2-OR agonist deltorphin II (0.12 mg/kg) and the proposed delta2-OR agonists deltorphin D (0.3 mg/kg) and/or dermorphin H (0.23 mg/kg) increases cardiac resistance to the arrhythmogenic action of acute ischemia and reperfusion. "
05/01/2004 - "Serum from hibernating woodchucks (hibernation induction trigger [HIT]), from summer nonhibernating animals (summer woodchuck active plasma [SWAP], and potential "hibernation opioid mimics" (D-Ala(2) D Leu(5) Enkephalin [DADLE]), and Deltorphin D (Delt D) were used as ischemic preconditioning agents (IPC) in an in vivo surgically induced cardiac ischemia rat model. "
01/01/2014 - "Anesthetized open-chest male Wistar rats were subjected to either 45 minutes of left coronary artery occlusion (phase 1a 10 minutes and phase 2b 35 minutes) and 2 hours of reperfusion in Experiment 1 or 10 minutes of ischemia and 10 minutes of reperfusion in Experiment 2. In Experiment 1, saline or vehicle controls and the mu-specific opioids dermorphin-H (Derm-H) and ([d-Ala2, N-Me-Phe4, Gly-ol5] enkephalin (DAMAGO); the delta-1-specific opioid d-Pen2,5enkephalin (DPDPE); nociceptin; and the delta-2-specific opioids deltorphin-II (Delt-II), Delt-Dvariant (Delt-Dvar), and deltorphin-E (Delt-E) were infused 15 minutes prior to ischemia. "
5. Contracture

Related Drugs and Biologics

1. delta Opioid Receptors (delta Opioid Receptor)
2. Ala(2)- deltorphin II
3. Enkephalins
4. D-Penicillamine (2,5)- Enkephalin
5. Insulin (Novolin)
6. naltrindole
7. Opioid Receptors (Opioid Receptor)
8. Narcotic Antagonists (Opioid Antagonists)
9. Naltrexone (ReVia)
10. Catecholamines

Related Therapies and Procedures

1. Injections
2. Analgesia
3. Aftercare (After-Treatment)