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Sd(C)28
28-residue oligodeoxycytidylate with sulfur substituted at a nonbridge oxygen of each phosphate atom
Also Known As:
S(dC)28; SdC28
Networked:
1
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Nucleic Acids, Nucleotides, and Nucleosides: 1
Nucleotides: 15763
Polynucleotides: 218
Oligonucleotides: 5145
Oligodeoxyribonucleotides: 2217
Sd(C)28: 1
Thionucleotides
Sd(C)28: 1
Organic Chemicals: 133
Sulfur Compounds: 278
Thionucleotides
Sd(C)28: 1
Related Diseases
1.
Neoplasms (Cancer)
10/29/1999 - "
Investigation of the ability of tumor cells to degrade heparan sulfate in intact extracellular matrix revealed that heparanase activity expressed by B16-BL6 mouse melanoma cells and 13762 MAT rat mammary adenocarcinoma cells was effectively inhibited by LS (50% inhibition at 0.2-1 microgram/ml), but there was no inhibition by sodium laminarin up to a concentration of 50 microgram/ml. Complete inhibition of the melanoma heparanase was obtained in the presence of 0.1 microM SdC28.
"
10/29/1999 - "
We investigated the effect of a chemically sulfated polysaccharide (laminarin), consisting primarily of beta-1,3 glucan (sodium laminarin), and of synthetic phosphorothioate oligodeoxynucleotides, primarily phosphorothioate homopolymer of cytidine (SdC28), on heparanase activity and tumor metastasis.
"
2.
Neoplasm Metastasis (Metastasis)
10/29/1999 - "
We investigated the effect of a chemically sulfated polysaccharide (laminarin), consisting primarily of beta-1,3 glucan (sodium laminarin), and of synthetic phosphorothioate oligodeoxynucleotides, primarily phosphorothioate homopolymer of cytidine (SdC28), on heparanase activity and tumor metastasis.
"
3.
Melanoma (Melanoma, Malignant)
10/29/1999 - "
Investigation of the ability of tumor cells to degrade heparan sulfate in intact extracellular matrix revealed that heparanase activity expressed by B16-BL6 mouse melanoma cells and 13762 MAT rat mammary adenocarcinoma cells was effectively inhibited by LS (50% inhibition at 0.2-1 microgram/ml), but there was no inhibition by sodium laminarin up to a concentration of 50 microgram/ml. Complete inhibition of the melanoma heparanase was obtained in the presence of 0.1 microM SdC28.
"
4.
Adenocarcinoma
10/29/1999 - "
Investigation of the ability of tumor cells to degrade heparan sulfate in intact extracellular matrix revealed that heparanase activity expressed by B16-BL6 mouse melanoma cells and 13762 MAT rat mammary adenocarcinoma cells was effectively inhibited by LS (50% inhibition at 0.2-1 microgram/ml), but there was no inhibition by sodium laminarin up to a concentration of 50 microgram/ml. Complete inhibition of the melanoma heparanase was obtained in the presence of 0.1 microM SdC28.
"
Related Drugs and Biologics
1.
Sodium
2.
Polysaccharides (Glycans)
3.
Oligodeoxyribonucleotides
4.
Heparitin Sulfate (Heparan Sulfate)
5.
Glucans
6.
Cytidine
7.
heparanase
8.
laminaran