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S 312

structure given in first source
Also Known As:
S-312; S-312-d; methyl 4,7-dihydro-3-isobutyl-6-methyl-4-(nitrophenyl)thieno(2,3-b)-pyridine-5-carboxylate; Thieno(2,3-b)pyridine-5-carboxylic acid, 4,7-dihydro-6-methyl-3-(2-methylpropyl)-4-(3-nitrophenyl)-, methyl ester, (+-)-
Networked: 6 relevant articles (3 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Aihua, Zhu: 1 article (07/2004)
2. Amano, Taku: 1 article (07/2004)
3. Matsubayashi, Hiroaki: 1 article (07/2004)
4. Sakai, Norio: 1 article (07/2004)
5. Sasa, Masashi: 1 article (07/2004)
6. Seki, Takahiro: 1 article (07/2004)
7. Serikawa, Tadao: 1 article (07/2004)

Related Diseases

1. Ischemia
2. Essential Hypertension
3. Body Weight (Weight, Body)
4. Stroke (Strokes)
12/01/1993 - "Histological examination of the brain of SHRSP showed that the arbitrary neurotoxic index (ANI) for stroke lesion dose-dependently decreased with S-312-d at 1, 3, and 10 mg/kg as follows: 4.8, 3.0, 2.3. "
12/01/1993 - "The therapeutic effects of nicardipine (ANI 3.9) at 10 mg/kg corresponded to those of S-312-d at 3 mg/kg. Thus, S-312-d can be recommended for the treatment of cerebral insufficiency or vasospasm following stroke as well as in essential hypertension."
12/01/1993 - "The prophylactic and therapeutic effects of S-312-d (S-(+)-methyl-4,7-dihydro-3-isobutyl-6-methyl-4-(3-nitrophenyl)thieno[2, 3- b]pyridine-5-carboxylate, CAS 120056-57-7) were compared with those of nimodipine or nicardipine using male stroke-prone spontaneously hypertensive rats (SHRSP). "
12/01/1993 - "Moderate diuretic effects were observed with S-312-d at doses of 1 and 3 mg/kg. The appearance of urinary occult blood in control SHRSP was markedly inhibited with S-312-d at 1 mg/kg and nimodipine at 10 mg/kg. Histological examination of the brain of SHRSP showed that cerebral stroke lesion including edema, hemorrhage, and/or softening was dose-dependently inhibited with S-312-d. "
12/01/1993 - "Hypotensive and antihypertensive effects of S-312-d (S-(+)-methyl-4,7-dihydro-3-isobutyl-6-methyl-4-(3-nitrophenyl)thieno[2, 3- b]pyridine-5-carboxylate, CAS 120056-57-7) in Wistar Kyoto rat (WKY), spontaneously hypertensive rat (SHR), stroke-prone SHR (SHRSP), and DOCA-salt hypertensive rat (DOCA-HR) were compared with those of other representative calcium antagonists. "
5. Epilepsy (Aura)

Related Drugs and Biologics

1. benzocycloheptapyridine
2. Calcium
3. Desoxycorticosterone Acetate (DOCA)
4. Therapeutic Uses
5. Glutamic Acid (Glutamate)
6. Taurine
7. Salts
8. Nimodipine (Modus)
9. Nicardipine (Dagan)
10. Diuretics

Related Therapies and Procedures

1. Oral Administration
2. Therapeutics