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N- (2- chloro- 6- methylergoline- 8- yl)- 2,2- dimethylpropanamide
Also Known As:
SDZ 208-912; SDZ HDC 912; SDZ-208-912
Networked:
3
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Alkaloids: 5398
Ergot Alkaloids: 208
Ergolines: 109
N-(2-chloro-6-methylergoline-8-yl)-2,2-dimethylpropanamide: 3
Fused-Ring Heterocyclic Compounds
4 or More Rings Heterocyclic Compounds
Ergolines: 109
N-(2-chloro-6-methylergoline-8-yl)-2,2-dimethylpropanamide: 3
Experts
1.
Kikuchi, Tetsuro
: 1 article (02/2012)
2.
Tadori, Yoshihiro
: 1 article (02/2012)
Related Diseases
1.
Schizophrenia (Dementia Praecox)
01/01/1990 - "
SDZ 208-911 and SDZ 208-912 could be effective against both the positive and negative symptoms of schizophrenia, while exhibiting a reduced incidence of dystonic and parkinsonian side-effects.
"
02/01/2012 - "
Aripiprazole's intrinsic activities at D2 and D9 receptors were lower than those observed with partial agonists (terguride, bifeprunox, OPC-4392 and (-)-3-PPP), which demonstrated clinically suboptimal improvement of positive symptoms of schizophrenia patients, and higher than that of SDZ 208-912, which demonstrated incidence of extrapyramidal symptoms similar to haloperidol.
"
2.
Vomiting
06/24/1993 - "
Neither (-)-3-PPP nor SND 919 produced dystonia, but had observable dopamine D2 receptor agonistic effects, (-)-3-PPP producing emesis at 1-4 mg/kg and SND 919 producing motoric unrest and stereotypy at 0.05-0.25 mg/kg. Comparing the antiamphetamine effects of the more antagonist-like drugs with raclopride, the relative potencies were terguride = SDZ HAC-911 > SDZ HDC-912 > raclopride.
"
3.
Dystonia (Limb Dystonia)
06/24/1993 - "
Neither (-)-3-PPP nor SND 919 produced dystonia, but had observable dopamine D2 receptor agonistic effects, (-)-3-PPP producing emesis at 1-4 mg/kg and SND 919 producing motoric unrest and stereotypy at 0.05-0.25 mg/kg. Comparing the antiamphetamine effects of the more antagonist-like drugs with raclopride, the relative potencies were terguride = SDZ HAC-911 > SDZ HDC-912 > raclopride.
"
Related Drugs and Biologics
1.
N- (2,6- dimethylergoline- 8- yl)- 2,2- dimethylpropanamide
2.
Raclopride
3.
Dopamine D2 Receptors (Dopamine D2 Receptor)
4.
Haloperidol (Haldol)
5.
Pramipexole (Mirapex)
6.
Aripiprazole (Abilify)
7.
dironyl (terguride)