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2',4'-dihydroxychalcone

RN given refers to (E)-isomer; RN for cpd without isomeric designation not available 6/89; structure given in first source

Networked: 6 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Blanco-Abad, Verónica: 1 article (02/2022)
2.	Dirks, Ron P H: 1 article (02/2022)
3.	Lamas, Jesús: 1 article (02/2022)
4.	Leiro, José Manuel: 1 article (02/2022)
5.	Raaijmakers, Jos: 1 article (02/2022)
6.	Sueiro, Rosa Ana: 1 article (02/2022)
7.	de Bruijn, Irene: 1 article (02/2022)
8.	Flores, Susana: 1 article (02/2021)
9.	Madrid, Alejandro: 1 article (02/2021)
10.	Montenegro, Iván: 1 article (02/2021)

Related Diseases

1.	Neoplasms (Cancer) 02/01/2021 - "Ultrasound assisted synthesis and cytotoxicity evaluation of known 2',4'-dihydroxychalcone derivatives against cancer cell lines." 12/01/2015 - "As a main component of Herba oxytropis, 2',4'-dihydroxychalcone (TFC) is known to demonstrate anti-tumor activity in vitro. " 08/01/2009 - "Preliminary studies on anti-tumor activity of 2',4'-dihydroxychalcone isolated from Herba Oxytropis in human gastric cancer MGC-803 cells." 08/01/2009 - "2',4'-Dihydroxychalcone (TFC), one of the main components in Herba Oxytropis, belongs to the flavonoid group, which is known to have anti-tumor activity in vitro. "
2.	Stomach Neoplasms (Stomach Cancer) 08/01/2009 - "Preliminary studies on anti-tumor activity of 2',4'-dihydroxychalcone isolated from Herba Oxytropis in human gastric cancer MGC-803 cells."
3.	Hepatocellular Carcinoma (Hepatoma) 01/17/2008 - "In this study, the hydroalcoholic extract of Zuccagnia punctata and 2',4'-dihydroxychalcone isolated from it were investigated for genotoxicity/antigenotoxicity in the in vitro comet assay test on human hepatoma HepG2 cells. "
4.	Ulcer 10/01/1992 - "Among the compounds tested, 2',4'-dihydroxychalcone gave the strongest activity in both experimental models and protected the gastric mucosa from the insult of either necrotizing agent at oral doses ranging from 1 to 10 mg/kg, as evidenced by a dose-related reduction in the ulcer index. " 10/01/1992 - "In fact, 2',4'-dihydroxychalcone prevented ulcer formation induced by water-immersion stress in rats and also showed a marked enhancement of the healing of acetic acid-induced gastric ulcers in rats."
5.	Stomach Ulcer (Gastric Ulcer) 10/01/1992 - "These results established that 2',4'-dihydroxychalcone is a potent cytoprotective agent similar to PGE2 effectively preventing gastric ulcer formation induced by strong necrotizing agents and seems to suggest that this compound protects the stomach against its own peptic secretions by reinforcement of gastric resistances. " 10/01/1992 - "In fact, 2',4'-dihydroxychalcone prevented ulcer formation induced by water-immersion stress in rats and also showed a marked enhancement of the healing of acetic acid-induced gastric ulcers in rats."

Related Drugs and Biologics

1.	Flavonoids
2.	Acetic Acid (Vinegar)
3.	Dinoprostone (PGE2)