RG 12525

leukotriene D4 antagonist; structure in first source

Also Known As:

(5-((2-(4-(2-quinolinylmethoxy)phenoxy)methyl)phenyl)methyl)-1H-tetrazole; RG-12525; Quinoline, 2-((4-((2-(1H-tetrazol-5-ylmethyl)phenyl)methoxy)phenoxy)methyl)-

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Tetrazoles: 14
      - RG 12525: 5
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - RG 12525: 5

Related Diseases

1.	Asthma (Bronchial Asthma) 04/01/1990 - "Compound 27 [RG 12525, 5-[[2-[[4-(2-quinolinylmethoxy)phenoxy]- methyl]phenyl]methyl]-1H-tetrazole] represents the best combination of in vitro and in vivo biological activity in this series and has been selected for further evaluation in clinical studies of asthma." 10/01/1991 - "We conclude that RG 12525 when administered orally is an effective LTD4 antagonist in subjects with mild asthma." 10/01/1991 - "We have studied the effect of RG 12525, an oral leukotriene D4 (LTD4) antagonist, on LTD4-induced bronchoconstriction in eight male subjects with mild asthma (baseline FEV1 greater than 80% predicted) in a double-blind, placebo-controlled fashion. " 10/01/1991 - "Effect of RG 12525, an oral leukotriene D4 antagonist, on the airway response to inhaled leukotriene D4 in subjects with mild asthma."
2.	Anaphylaxis (Anaphylactic Shock) 01/01/1989 - "Antagonism of peptidoleukotrienes and inhibition of systemic anaphylaxis by RG 12525 in guinea pigs." 06/01/1989 - "The compound inhibited antigen-induced mortality in the systemic anaphylaxis model with an ED50 (95% confidence interval) = 2.2 (0.8-6.4) mg/kg. In this model, the activity half-life of RG 12525 was shown to be 6.5 hours and the compound offered significant protection within 15 minutes of administration. "
3.	Hypertrophy 11/01/1995 - "High doses of RG 12525 caused significant increases in liver weight in mice, rats, and monkeys that were associated with diffuse hepatocellular hypertrophy in mice and rats but not in monkeys. "

Related Drugs and Biologics

1.	1H-tetrazole (tetrazole)
2.	Leukotriene D4
3.	Antigens