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ME 2303
structure given in first source; RN given refers to (2S-cis)-isomer
Also Known As:
7-O-(2,6-dideoxy-2-fluoro-alpha-talopyranosyl)pimelyladriamcycinone; FAD 104; FAD-104; ME-2303; ME2302
Networked:
4
relevant articles (
2
outcomes,
1
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Polycyclic Aromatic Hydrocarbons: 2020
Naphthacenes
Anthracyclines: 9423
Daunorubicin: 2641
Doxorubicin: 35390
ME 2303: 4
Polycyclic Compounds: 6
Polycyclic Aromatic Hydrocarbons: 2020
Naphthacenes
Anthracyclines: 9423
Daunorubicin: 2641
Doxorubicin: 35390
ME 2303: 4
Carbohydrates: 22023
Glycosides: 2119
Aminoglycosides: 5131
Anthracyclines: 9423
Daunorubicin: 2641
Doxorubicin: 35390
ME 2303: 4
Related Diseases
1.
Neoplasms (Cancer)
06/01/1990 - "
Thirty-five mg/kg of ME 2303 was effectively inhibited tumor growth against 3 lines, with marked efficacy against 2 lines.
"
06/01/1991 - "
To evaluate the cardiotoxicity of ME 2303, ECG tracings (21 patients) and Holter ECGs (9 patients) were recorded before and after the administration of ME 2303 for various malignancies (mean dose 123.8 mg/m2), and some of the electrocardiographic parameters were analyzed.
"
2.
Colorectal Neoplasms (Colorectal Cancer)
06/01/1990 - "
On the other hand, 50 mg/kg of ME 2303 was also effective against 4 lines tested (2 each of gastric and colorectal cancers), with marked efficacy against 3. In all, ME 2303 was more effective than doxorubicin except one of stomach cancer.
"
3.
Stomach Neoplasms (Stomach Cancer)
06/01/1990 - "
On the other hand, 50 mg/kg of ME 2303 was also effective against 4 lines tested (2 each of gastric and colorectal cancers), with marked efficacy against 3. In all, ME 2303 was more effective than doxorubicin except one of stomach cancer.
"
4.
Myeloid Leukemia (Leukemia, Myelocytic)
01/01/1989 - "
Therefore, FAD-104 may be useful in the treatment of some forms of myeloid leukemia.
"
01/01/1989 - "
In addition, FAD-104 but not ADM induced a clonal down-grading in both normal and leukemic blast cells, and it stimulated the terminal differentiation of myeloid leukemia cells.
"
5.
Cardiotoxicity
06/01/1991 - "
To evaluate the cardiotoxicity of ME 2303, ECG tracings (21 patients) and Holter ECGs (9 patients) were recorded before and after the administration of ME 2303 for various malignancies (mean dose 123.8 mg/m2), and some of the electrocardiographic parameters were analyzed.
"
06/01/1991 - "
[Evaluation of cardiotoxicity in new anthracycline analog ME 2303.
"
01/01/1993 - "
Anthracyclines including SM-5887, KRN-8602, ME-2303 under studies in Japan have shown comparable or superior antitumor activities and lower cardiac toxicities compared to doxorubicin in preclinical studies and therefore the results obtained in clinical trials are expected.
"
Related Drugs and Biologics
1.
Doxorubicin (Adriamycin)
2.
Anthracyclines
3.
amrubicin
4.
morpholinoanthracycline MX2 (MX-2)