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purpurin 18

isolated from chlorophyll; structure given in first source; RN from Chemical Abstracts Index Guide

Also Known As:

PP-18; purpurin-18

Networked: 10 relevant articles (2 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Drašar, Pavel: 2 articles (12/2019 - 03/2017)
2.	Jurášek, Michal: 2 articles (12/2019 - 03/2017)
3.	Ruml, Tomáš: 2 articles (12/2019 - 03/2017)
4.	Liang, Mengyun: 1 article (12/2021)
5.	Ma, Xianbin: 1 article (12/2021)
6.	Sun, Zhi-Jun: 1 article (12/2021)
7.	Xiao, Yao: 1 article (12/2021)
8.	Xu, Zhigang: 1 article (12/2021)
9.	Yang, Lei-Lei: 1 article (12/2021)
10.	Yang, Qi-Chao: 1 article (12/2021)

Related Diseases

1.	Neoplasms (Cancer) 12/06/2019 - "PEGylated Purpurin 18 with Improved Solubility: Potent Compounds for Photodynamic Therapy of Cancer." 03/01/2017 - "In vitro studies on several cancer cells indicated that conjugation of purpurin 18 with spermine increased its retention in cancer cells. " 02/01/2013 - "The results showed that the cells were killed immediately after PDT and purpurin-18 had no different efficacy to different cancer cell lines. " 10/26/2006 - "Since the tumor tissues contain numerous lipoprotein receptors, chlorin p(6) and purpurin 18 could be internalized more efficiently in tumor cells." 10/26/2006 - "However, it is possible that this factor may not be a problem for cellular uptake of chlorin p(6) and purpurin 18 by the tumor tissues, since it binds more efficiently with low-density lipoprotein when it become more lipophilic, indicating that the principal carriers for these molecules are lipoproteins. "
2.	Triple Negative Breast Neoplasms 03/01/2021 - "This study aims to evaluate the photodynamic efficacy of purpurin 18 (pu-18) on triple negative breast cancer both in vitro and in vivo. " 03/01/2021 - "Photodynamic treatment with purpurin 18 effectively inhibits triple negative breast cancer by inducing cell apoptosis."
3.	Phototoxic Dermatitis (Phototoxicity) 04/01/2006 - "Pharmacokinetics and phototoxicity of purpurin-18 (Pp18) in human colon carcinoma cells (Colo-205) was studied using liposomes as delivery vehicles. " 04/01/2006 - "Pharmacokinetics and phototoxicity of purpurin-18 in human colon carcinoma cells using liposomes as delivery vehicles." 03/01/2017 - "This combined with its high phototoxicity makes the purpurin 18/spermine conjugate a promising photosensitizer for PDT. "
4.	Necrosis 03/01/2001 - "We report here that Purpurin-18 (Pu18) in combination with light induces rapid apoptotic cell death in the human leukemia cell line (HL60) at low doses and necrosis at higher concentrations. " 03/01/2001 - "Purpurin-18 in combination with light leads to apoptosis or necrosis in HL60 leukemia cells."
5.	Leukemia 03/01/2001 - "We report here that Purpurin-18 (Pu18) in combination with light induces rapid apoptotic cell death in the human leukemia cell line (HL60) at low doses and necrosis at higher concentrations. " 03/01/2001 - "Purpurin-18 in combination with light leads to apoptosis or necrosis in HL60 leukemia cells."

Related Drugs and Biologics

1.	1-phenyl-3,3-dimethyltriazene (PDT)
2.	Liposomes (Liposome)
3.	Doxorubicin (Adriamycin)
4.	Spermine
5.	Sodium
6.	Salts
7.	Photosensitizing Agents (Photosensitizers)
8.	Therapeutic Uses
9.	Lipoprotein Receptors (Lipoprotein Receptor)
10.	Reactive Oxygen Species (Oxygen Radicals)

Related Therapies and Procedures

1.	Photochemotherapy (Photodynamic Therapy)
2.	Therapeutics
3.	Drug Therapy (Chemotherapy)