NC 190

structure given in first source

Also Known As:

N-beta-dimethylaminoethyl-9-carboxy-5-hydroxy-10-methoxybenzo(a)phenazine-6-carboxamide; NC-190; Benzo(a)phenazine-9-carboxylic acid, 6-(((2-(dimethylamino)ethyl)amino)carbonyl)-5-hydroxy-10-methoxy-, monosodium salt

Networked: 6 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Phenazines: 42
      - NC 190: 6

Experts

1.	Gibbs, John F: 1 article (01/2005)
2.	Rustum, Youcef M: 1 article (01/2005)
3.	Slocum, Harry K: 1 article (01/2005)
4.	Igarashi, Kazuei: 1 article (01/2002)
5.	Ikeda, Tomotake: 1 article (01/2002)
6.	Kashiwagi, Keiko: 1 article (01/2002)
7.	Kuraishi, Aiko: 1 article (01/2002)
8.	Nakaike, Shiro: 1 article (01/2002)
9.	Samata, Kazunori: 1 article (01/2002)
10.	Tanaka, Makoto: 1 article (01/2002)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2005 - "Fifty-five percent (28/51) of fresh human tumors showed sensitivity to 48-h exposure to 10, 30, or 100 microM NC-190. " 01/01/1993 - "NC-190 is a novel benzophenazine derivative with excellent antitumor activities against murine tumors. " 07/01/1990 - "Therefore, the antitumor activity of NC-190 in the double grafted tumor system was judged as associated with a sequential immune mechanism in which T cells may play an important role. " 07/01/1990 - "In BALB/c nude mice, NC-190 inhibited slightly the growth of the right tumor but did not that of the left tumor. " 07/01/1990 - "These results suggest that intratumoral administration of NC-190 might induce Lyt-2 positive cytotoxic cells in the spleen and the left, non-treated tumor. "
2.	Leukemia P388 01/01/1989 - "In the initial studies with P388 leukemia (i.p.-i.p.), NC-190 led to an increase of greater than 200% in life span (ILS), and 75% of the mice were alive on day 30, when the optimal dose (50 mg/kg, days 1-5) was given. " 01/01/1990 - "When vincristine (VCR)-resistant P388 leukemia-bearing mice were treated with an optimal dose of NC-190, four of six mice were cured, whereas treatment of mice with VCR resulted in only a marginal increase in life span. "
3.	Neoplasm Metastasis (Metastasis) 01/01/1989 - "NC-190 warrants further study as a potential antineoplastic agent against human neoplasms, as it has a broad spectrum of antitumor activity and inhibits metastasis."
4.	Lewis Lung Carcinoma 01/01/1989 - "inoculated tumors, NC-190 not only inhibited tumor growth, but also increased the life span of mice with Lewis lung carcinoma or B16 melanoma. "
5.	Sarcoma (Soft Tissue Sarcoma) 07/01/1990 - "TILs (tumor infiltrating lymphocytes) obtained from the left and right sides tumors treated with NC-190 were examined by Winn assay for their antitumor activity against Meth-A sarcoma in BALB/c mice. "

Related Drugs and Biologics

1.	Vincristine (Oncovin)
2.	phenazine
3.	Topoisomerase II Inhibitors
4.	Antineoplastic Agents (Antineoplastics)
5.	Member 1 Subfamily B ATP Binding Cassette Transporter
6.	Thymidine Kinase
7.	Messenger RNA (mRNA)
8.	Type II DNA Topoisomerases (Topoisomerase II)