kinamycin F

isolated from Streptomyces murayamaensis; structure given in first source

Also Known As:

5H-Benzo(b)carbazole-5-carbonitrile, 1,2,3,4,6,11-hexahydro-1,2,3,4,7-pentahydroxy-3-methyl-6,11-dioxo-, (1alpha,2beta,3alpha,4alpha)-

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

1.	Osteosarcoma (Osteogenic Sarcoma) 01/01/2017 - "Cell Cycle Arrest and Apoptosis Induced by Kinamycin F in Human Osteosarcoma Cells." 01/01/2017 - "Finally, kinamycin F suppressed osteosarcoma cell proliferation affecting cyclin A and D3 expression. " 01/01/2017 - "In this study, the potential anti-tumor activity of kinamycin F was investigated in three human osteosarcoma cell lines, MG-63, U-2 OS and HOS as an antitumor agent with a potentially novel target. "
2.	Neoplasms (Cancer) 01/01/2017 - "In this study, the potential anti-tumor activity of kinamycin F was investigated in three human osteosarcoma cell lines, MG-63, U-2 OS and HOS as an antitumor agent with a potentially novel target. "
3.	Leukemia 03/30/2010 - "Kinamycin F downregulates cyclin D3 in human leukemia K562 cells." 10/15/2007 - "Consistent with this idea, 2-oxo-4-thiazolidinecarboxylic acid treatment to increase cellular GSH levels and buthionine sulfoximine treatment to decrease GSH levels resulted in decreased and increased kinamycin F cytotoxicity, respectively, in K562 leukemia cells. "

1.	Antineoplastic Agents (Antineoplastics)
2.	Cyclin D3
3.	Cyclin A
4.	Buthionine Sulfoximine
5.	Acids