AHC 52

structure given in first source

Also Known As:

AHC-52; methyl 2-(N-benzyl-N-methylamino)ethyl-2,6-dimethyl-4-(2-isopropylpyrazolo(1,5-a)pyridine-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-(1-methylethyl)pyrazolo(1,5-a)pyridin-3-yl)-, methyl 2-(methyl(phenylmethyl)amino)ethyl ester

Networked: 4 relevant articles (2 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrazoles: 61
      - AHC 52: 4
  - Pyridines: 88
    - Dihydropyridines: 214
      - AHC 52: 4

Related Diseases

1.	Leukemia P388 01/01/1992 - "On the other hand, AHC-52 strongly augmented the therapeutic efficacy of these antitumor agents in mice bearing the sensitive parent P388 leukemia, producing some curative effects. " 01/01/1992 - "Therapeutic efficacy of combination of antitumor agent with AHC-52 against multidrug-resistant cells in the intravenously inoculated P388 leukemia model." 04/01/1989 - "In vivo circumvention of vincristine resistance in mice with P388 leukemia using a novel compound, AHC-52."
2.	Reperfusion Injury 12/01/1997 - "Thus, AHC-52 inhibits Cl- channels in cardiac muscle and may have protective effects against ischemia-reperfusion injury." 12/01/1997 - "Cardioprotective effect against ischemia-reperfusion injury of AHC-52, a dihydropyridine compound with inhibitory effect on Cl- but not Ca2+ current."
3.	Ischemia 12/01/1997 - "AHC-52 (0.1 microM) had no effect on developed tension under normal conditions and during ischemia, but significantly improved the recovery of developed tension after reperfusion to about 80% of preischemic values. "
4.	Neoplasms (Cancer) 04/01/1989 - "A novel compound partially analogous to nifedipine, AHC-52, was found to sensitize multidrug-resistant tumor cells. " 03/01/1990 - "As synthetic potentiators, dipyridamole, cepharanthine, AHC-52 and analogs of dihydropyridines were described; all of them were thought to interact with a P-glycoprotein and inhibit active efflux of drugs from tumor cells. "
5.	Leukemia 01/01/1992 - "To predict the clinical effect on leukemic disease of a combination regimen developed to circumvent multidrug resistance (MDR), we tested various antitumor agents in the presence and absence of AHC-52, a sensitizing agent for multidrug-resistant cells, in the i.v.-i.v. model of murine leukemia. "

Related Drugs and Biologics

1.	Antineoplastic Agents (Antineoplastics)
2.	Member 1 Subfamily B ATP Binding Cassette Transporter
3.	Vincristine (Oncovin)
4.	Nifedipine (Adalat)
5.	Dipyridamole (Persantine)
6.	Dihydropyridines
7.	1,4-dihydropyridine (dihydropyridine)
8.	cepharanthine