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isbufylline

RN from Toxlit

Also Known As:

1,3-dimethyl-7-isobutylxanthine; TE 06; TE-06

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Purinones: 2
        Xanthines: 123
        Theophylline: 4197
        1-Methyl-3-isobutylxanthine: 183
        isbufylline: 3

Related Diseases

1.	Dyspnea (Shortness of Breath) 11/16/1993 - "At a dose (106 mumol kg-1 i.p.) providing complete protection against acetylcholine aerosol-induced dyspnea in the guinea pig, isbufylline inhibited platelet activating factor (PAF)- and antigen-induced eosinophil infiltration into bronchoalveolar lavage fluid 24 h after challenge of normal and actively immunized guinea pigs, respectively. " 11/16/1993 - "On the other hand the bronchodilator, salbutamol, at a dose (10.4 mumol kg-1 i.p.) shown to be equieffective to isbufylline (106 mumol kg-1 i.p.) for blocking acetylcholine aerosol-induced dyspnea, had no protective action against PAF- or antigen-induced eosinophil recruitment in bronchoalveolar lavage fluid, or against capsaicin-induced plasma protein extravasation. "
2.	Seizures (Absence Seizure) 11/03/1992 - "No enprofylline- or isbufylline-treated rats developed seizures or died. "
3.	Respiratory Hypersensitivity 11/16/1993 - "The pharmacological actions of the new xanthine, isbufylline, were evaluated in several models of airway hyperresponsiveness and airway inflammation in guinea pigs. " 11/16/1993 - "Isbufylline, a new xanthine derivative, inhibits airway hyperresponsiveness and airway inflammation in guinea pigs."
4.	Inflammation (Inflammations) 11/16/1993 - "The pharmacological actions of the new xanthine, isbufylline, were evaluated in several models of airway hyperresponsiveness and airway inflammation in guinea pigs. " 11/16/1993 - "Isbufylline, a new xanthine derivative, inhibits airway hyperresponsiveness and airway inflammation in guinea pigs."
5.	Bronchial Spasm 11/01/1990 - "Isbufylline is significantly more effective than theophylline in antagonizing bronchospasms elicited by spasmogens (capsaicin, arachidonic acid, PAF and antigen) which mainly act by a local release of biologically active substances proposed to be involved in the pathogenesis of asthma. "

Related Drugs and Biologics

1.	Antigens
2.	Platelet Activating Factor
3.	Aerosols
4.	Acetylcholine (Acetylcholine Chloride)
5.	Capsaicin (Zostrix)
6.	Xanthine
7.	Arachidonic Acid (Vitamin F)
8.	Theophylline (Theon)
9.	Bronchodilator Agents (Bronchodilators)
10.	Blood Proteins (Serum Proteins)