HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

1,2,3-tribromo-2-methylpropane

Also Known As:

TBMP

Networked: 7 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Halogenated Hydrocarbons: 42
    - Brominated Hydrocarbons: 1
      - 1,2,3-tribromo-2-methylpropane: 7

Experts

1.	Hashizume, H: 1 article (04/2001)
2.	Kawakami, M: 1 article (04/2001)
3.	Minamide, A: 1 article (04/2001)
4.	Sakata, R: 1 article (04/2001)
5.	Tamaki, T: 1 article (04/2001)

Related Diseases

1.	Neoplasms (Cancer) 08/01/1986 - "These findings indicate that PTBP and TBMP may be carcinogenic for hamster forestomach after long-term administration, and that both one hydroxy and tert-butyl substituents may be important for induction of hamster forestomach tumors." 03/01/1990 - "The present results demonstrated strong proliferative responses in the stomach epithelium for CC and TBMP, indicative of promoting potential in both cases, and suggest that CC and TBMP may exert detrimental effects leading to promotion of stomach carcinogenesis or cancer development via an early proliferative response." 01/01/1988 - "Mammary tumor development was reduced by diet containing TMPD, PG, TBMP, TBHQ or GG, although this could be partly due to antioxidant treatment-associated decrease in body wt gain. " 08/01/1990 - "The urinary bladder tumor-promoting potentials of the phenolic antioxidants, 2-tert-butyl-4-methylphenol (TBMP), propylparaben, catechol, resorcinol and hydroquinone, which are structurally related to butylated hydroxyanisole (BHA), were investigated in 170 male F344 rats. "
2.	Carcinogenesis 03/01/1990 - "The present results demonstrated strong proliferative responses in the stomach epithelium for CC and TBMP, indicative of promoting potential in both cases, and suggest that CC and TBMP may exert detrimental effects leading to promotion of stomach carcinogenesis or cancer development via an early proliferative response." 08/01/1990 - "The similar effects of TBMP and BHA on urinary bladder carcinogenesis suggest a direct link between chemical structure and biological potency." 08/01/1990 - "The results thus clearly showed that TBMP, which most closely resembles BHA, promoted urinary bladder carcinogenesis. " 01/01/1988 - "The effects of the antioxidants tetramethyl-p-phenylenediamine (TMPD), propyl gallate (PG), quercetin (QC), 2-tert-butyl-4-methylphenol (TBMP), tert-butylhydroquinone (TBHQ), 3,3'-thiodipropionic acid (TDPA), guaiac gum (GG) and caffeic acid (CA) on 7,12-dimethylbenz[a]anthracene (DMBA)-initiated mammary gland, ear duct and forestomach carcinogenesis were examined in female Sprague--Dawley rats. "
3.	Hyperplasia 08/01/1990 - "Significant increases in the incidences and average numbers of the putative preneoplastic lesions, papillary or nodular (PN) hyperplasia, and papillomas of the urinary bladder were only observed in the group given TBMP after BBN. " 03/01/1990 - "Treatment with CC and TBMP induced a significant elevation of DNA synthesis in the forestomach epithelium, associated with hyperplasia. " 08/01/1986 - "Of these compounds, 2(3)-tert-butyl-4-methoxyphenol (BHA), 2-tert-butyl-4-methylphenol (TBMP) and p-tert-butylphenol (PTBP) strongly induced hyperplasia and tumorous lesions in the forestomach. "
4.	Papilloma (Papillomatosis) 08/01/1990 - "Significant increases in the incidences and average numbers of the putative preneoplastic lesions, papillary or nodular (PN) hyperplasia, and papillomas of the urinary bladder were only observed in the group given TBMP after BBN. "
5.	Lymphoma (Lymphomas) 12/01/1987 - "In the mouse lymphoma gene mutation assay, DBCP and TBMP were positive in the presence and absence of activation, while DBCMP was positive only in the absence of activation. "

Related Drugs and Biologics

1.	2-tert-butyl-4-methylphenol
2.	Butylated Hydroxyanisole (BHA)
3.	Antioxidants
4.	Quercetin
5.	Propyl Gallate
6.	Guaiac
7.	DNA (Deoxyribonucleic Acid)
8.	Acids
9.	1,2-dibromo-3-chloro-2-methylpropane
10.	caffeic acid