calphostin C

structure given in first source; isolated from Cladosporium cladosporioides

Also Known As:

UCN 1028 C; UCN 1028C; UCN-1028C; Carbonic acid, 2-(12-(2-(benzoyloxy)propyl)-3,10-dihydro-4,9-dihydroxy-2,6,7,11-tetramethoxy-3,10-dioxo-1-perylenyl)-1-methylethyl 4-hydroxyphenyl ester

Networked: 138 relevant articles (2 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Naphthalenes: 18
        calphostin C: 138
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Naphthalenes: 18
    - calphostin C: 138

Experts

1.	Zhang, Zhe: 5 articles (05/2017 - 06/2013)
2.	Li, Yin: 4 articles (06/2008 - 04/2004)
3.	Nie, Qiang: 4 articles (06/2008 - 04/2004)
4.	Zhu, Wen: 4 articles (06/2008 - 04/2004)
5.	Kong, Chuize: 3 articles (05/2017 - 06/2013)
6.	Fu, Junke: 3 articles (06/2008 - 04/2004)
7.	Li, Dingbiao: 3 articles (06/2008 - 04/2004)
8.	Liu, Lunxu: 3 articles (06/2008 - 04/2004)
9.	Zhou, Qinghua: 3 articles (06/2008 - 04/2004)
10.	Dewey, William L: 2 articles (01/2018 - 01/2017)

Related Diseases

1.	Neoplasms (Cancer) 11/01/2003 - "The photoactivatable drug calphostin C has shown promise in killing select drug-resistant tumor cells lines in vitro. " 06/01/2016 - "Based on the stimulation of endoplasmic reticulum stress in some types of cancer, calphostin C has also been evaluated as a potential photodynamic therapeutic agent. " 09/01/1999 - "Activated calphostin C cytotoxicity is independent of tumor genetic background and the status of p53 and pRb. " 10/01/1998 - "Treatment of these cancer cell lines with nanomolar concentrations of calphostin C in combination with increasing amounts of light exposure established a relationship between light and dose dependence of calphostin C cytotoxicity. " 10/01/1996 - "Furthermore, this MMP-2 activity could be inhibited by the treatment of tumor cells with calphostin C, a specific inhibitor of PKC. "
2.	Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse) 09/11/1998 - "We investigated the protective effects of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) on U937 histiocytic lymphoma cells induced to undergo apoptosis by tumor necrosis factor-alpha (TNF-alpha) or by the specific PKC inhibitor calphostin C. " 09/11/1998 - "Evidence that protein kinase Cepsilon mediates phorbol ester inhibition of calphostin C- and tumor necrosis factor-alpha-induced apoptosis in U937 histiocytic lymphoma cells."
3.	Glioma (Gliomas) 02/01/1997 - "In the current studies, we examined the effect of a novel PKC inhibitor, calphostin C, which is a selective, highly potent, photo-activatable inhibitor of the PKC regulatory domain, on the proliferation and viability of three established and three low-passage malignant glioma cell lines, four low-passage low-grade glioma cell lines, and in adult human and neonatal rat non-neoplastic astrocyte cell lines in vitro. " 06/01/2000 - "Calphostin C-mediated apoptosis in glioma cells was reported previously to be associated with down-regulation of Bcl-2 and Bcl-xL. " 12/01/1995 - "Together, these observations suggest that calphostin C is capable of inducing apoptotic DNA fragmentation and cell death in a highly concentration dependent manner in human glioma cells and that the apoptosis is closely associated with the decrease in transcription and translation of bcl-2." 10/01/1996 - "Glioma cell lines treated with calphostin C demonstrated a dose-dependent decrease (IC50 = 30 nM) in tumor invasiveness with a concomitant reduction in the activity of the MMP-2. " 11/01/2006 - "Photocytotoxic effect on the two glioma cell lines was similar with LD50 at optimal uptake: 1 microg/mL Photofrin at 1.5 J/cm(2); 1 mM 5-ALA at 2 J/cm(2) and 100 nM calphostin C at 2 J/cm(2). "
4.	Hypoxia (Hypoxemia) 01/01/2001 - "Under normoxic conditions, activation of PKC by phorbol-12-myristate-13-acetate (PMA; 100 nmol/L) markedly increased HO-1 gene expression, while inhibition of PKC activity by calphostin C (100 nmol/L) blocked hypoxia-induced HO-1 gene expression in cardiac myocytes. " 12/01/2004 - "To study this, isometric force displacement was measured in isolated rat pulmonary artery rings during hypoxia in the presence and absence of the PKC inhibitors calphostin C or chelerythrine. " 09/01/2001 - "Hypoxia to ECs increased ERK phosphorylation within 10 min and which was abolished by administration of PD98095, calphostin C, and BAPTA/AM. Hypoxia triggered a transient translocation of PKCalpha from cytosol to membrane fraction concurrent with the association of PKCalpha to Raf-1. " 09/01/2001 - "Addition of calphostin C, a protein kinase C (PKC) inhibitor, completely blocked the hypoxia-augmented Egr-1 expression. " 06/08/1999 - "When EPO-producing Hep3B cells were incubated in 1% O2 (hypoxia) for 24 h, PMA treatment resulted in significant decreases in medium levels of EPO in Hep3B cell cultures at concentrations higher than 10 nM. The specific PKC inhibitor, calphostin C, significantly inhibited medium levels of EPO and EPO mRNA levels in Hep3B cells exposed to 1% O2. "
5.	Hepatocellular Carcinoma (Hepatoma) 06/08/1999 - "Hep3B human hepatocellular carcinoma cells were used for this study and were depleted of PKC in three different ways: long-term treatment with phorbol 12-myristate 13-acetate (PMA), selective inhibition with calphostin C, and treatment with PKCalpha antisense oligonucleotides. " 06/01/2002 - "Using a specific inhibitor of protein kinase C (PKC), calphostin C, we show the requirement of this kinase in the induction process in human hepatoma HepG2 cells. " 12/01/1996 - "Constitutive secretion of heparan sulphate proteoglycans (HSPGs) was stimulated in human hepatoma HepG2 cells by phorbol 12-myristate 13-acetate (PMA) and inhibited by calphostin C, a specific inhibitor of protein kinase C (PKC). " 02/26/2010 - "Sphingosine is known to inhibit protein kinase C (PKC), and PKC inhibition with nanomolar concentrations of staurosporine, calphostin C, and GF109203X down-regulated surface expression of S1P(1) but not S1P(4) in transfected rat hepatoma HTC(4) cells. "

Related Drugs and Biologics

1.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
2.	Phorbol Esters
3.	Protein Kinase C
4.	chelerythrine
5.	Staurosporine
6.	N- (2- (4- bromocinnamylamino)ethyl)- 5- isoquinolinesulfonamide (h89)
7.	phorbol
8.	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)
9.	Protein Isoforms (Isoforms)
10.	Vasoconstrictor Agents

Related Therapies and Procedures

1.	Therapeutics
2.	Photochemotherapy (Photodynamic Therapy)
3.	Aftercare (After-Treatment)
4.	Ligation
5.	Lasers (Laser)