praeruptorin C

isolated from root of Peucedanum praeruptorum Dunn; RN from Toxlit; structure given in first source

Also Known As:

2-methyl-10-(acetyloxy)-9,10-dihydro-8,8-dimethyl-2-oxo-2H,8H-benzo(1,2-b:3,4-b)dipyran-9-ol ester of 2-butenolc acid; praeruptorine C

Networked: 9 relevant articles (1 outcomes, 0 trials/studies)

1.	Ischemia 01/01/1992 - "[Protective effects of praeruptorin C and nifedipine on ischemia-reperfused injury in working rat hearts]."
2.	Hypertrophy 03/01/2001 - "[Effects of praeruptorin C on vascular hypertrophy, [Ca2+]i, collagen content and NO in renovascular and spontaneously hypertensive rats]." 01/01/2002 - "To investigate the effects of praeruptorin C (Pra-C) on smooth muscle cell (SMC) hypertrophy, intracellular calcium ([Ca2+]i), nitric oxide (NO) content and influence on cellular signal transduction in isolated cultured rat smooth muscle cell (SMC). " 01/01/2002 - "[Effects of praeruptorin C on cell hypertrophy, intracellular [Ca2+]i, nitric oxide and signal transduction in isolated hypertrophied rat smooth muscle cells induced by angiotensin II]."
3.	Cognitive Dysfunction 10/01/2023 - "Praeruptorin C alleviates cognitive impairment in type 2 diabetic mice through restoring PI3K/AKT/GSK3β pathway."
4.	Myocardial Ischemia (Ischemic Heart Diseases) 01/01/1992 - "The effects of praeruptorin C (Pra-C, 15 mg/kg, bid x 3 d, ip) on global myocardial ischemia and reperfusion were investigated in the isolated working rat hearts. "
5.	Neoplasms (Cancer) 07/01/2018 - "Praeruptorin C and its derivatives play an important role in lowering blood pressure and dilating coronary arteries, and khellactone derivatives have significant inhibitory effects on AIDS, cancer, and cardiovascular diseases. "

1.	Nifedipine (Adalat)
2.	Nitric Oxide (Nitrogen Monoxide)
3.	Collagen
4.	Calcium
5.	Angiotensin II
6.	khellactone
7.	3-nitropropionic acid