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lansoprazole (Prevacid)

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K+/H+-ATPase antagonist; dexlansoprazole (TAK-390MR) is the enantiomer; structure given in first source

Also Known As:

Prevacid; 2-(((3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl)methyl)sulfinyl)-1H-benzimidazole; AG 1749; AG-1749; Abbot Brand of Lansoprazole; Agopton; Almirall Brand of Lansoprazole; Bamalite; Hoechst Brand of Lansoprazole; Hormona Brand of Lansoprazole; Lanzor; Lederle Brand of Lansoprazole; Monolitum; Ogast; Ogastro; Opiren; Prezal; Pro Ulco; Promeco; Promeco Brand of Lansoprazole; Salvar Brand of Lansoprazole; TAK 390MR; TAK-390MR; TAK390MR; TAP Brand of Lansoprazole; Takeda Brand of Lansoprazole; Takepron; Tecnobio Brand of Lansoprazole; Ulpax; Vinas Brand of Lansoprazole; Wyeth Brand of Lansoprazole; Zoton; dexlansoprazole; lansoprazole sulphone; lanzoprazole

Networked: 807 relevant articles (168 outcomes, 194 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Peura, David A: 9 articles (01/2015 - 06/2004)
2.	Huang, Bidan: 9 articles (01/2007 - 01/2002)
3.	Kinoshita, Yoshikazu: 8 articles (01/2015 - 02/2003)
4.	Atkinson, Stuart: 7 articles (05/2010 - 01/2008)
5.	Holbrook, Janet T: 6 articles (07/2015 - 01/2012)
6.	Lima, John J: 6 articles (07/2015 - 01/2012)
7.	Perez, M C: 6 articles (11/2013 - 04/2009)
8.	Haber, Marian M: 6 articles (05/2010 - 01/2002)
9.	Fass, R: 6 articles (06/2009 - 04/2000)
10.	Wong, W M: 6 articles (02/2006 - 06/2001)

Related Diseases

1.	Gastroesophageal Reflux (GERD) 09/01/2005 - "Step-down lansoprazole therapy is considered very effective in terms of rapid effect, long-term effect and high quality GERD treatment." 02/15/2004 - "Lansoprazole dosages of 30 mg and 15 mg once daily provide a satisfactory decrease for oesophageal acid exposure and are equally effective for the treatment of gastro-oesophageal reflux disease in the Chinese population." 03/01/2008 - "The objective of this study was to assess the clinical efficacy of 2 dosing regimens of lansoprazole in infants with GERD using the revised infant gastroesophageal reflux questionnaire scores (I-GERQ-R). " 01/01/2010 - "Results of multicenter study "Efficacy of Lansoptol (lansoprazole, KRKA) and its influence on the Dynamics of GERD symptoms" (LIEDER) are presented. " 12/01/2005 - "Impact of Helicobacter pylori eradication on the anti-secretory efficacy of lansoprazole in gastroesophageal reflux disease patients."
2.	Duodenal Ulcer (Curling's Ulcer) 08/10/1998 - "In patients with an active or a recent history of duodenal ulcer, lansoprazole-based triple therapy for 10 or 14 days is highly effective in the eradication of H pylori. " 04/01/1998 - "In patients with active or a recent history of duodenal ulcer, a 14-day course of lansoprazole-based triple therapy without additional acid suppression therapy is highly effective in the eradication of H. " 10/01/1996 - "Lansoprazole was effective for prompt symptom relief in most patients and was able to heal more than 90% of gastric and duodenal ulcers with minimal side effects." 10/01/1995 - "Lansoprazole is an effective and safe treatment for duodenal ulcer and the 15 mg dose is as effective as 30 or 60 mg." 09/01/1995 - "It is shown that lansoprazole is effective and safe for treatment of duodenal ulcer."
3.	Heartburn (Pyrosis) 09/01/2009 - "Both lansoprazole 15 and 30 mg were highly effective and well tolerated in reducing symptoms in subjects with frequent nighttime heartburn. " 08/20/2010 - "In addition, the proportion of 24-hour heartburn-free days (primary endpoint) was significantly greater in recipients of dexlansoprazole MR 30 mg once daily than in recipients of placebo following 4 weeks' treatment in a large, randomized, double-blind, multicentre phase III trial in patients with NERD. " 07/01/2001 - "Failure patients had significantly poorer health outcomes during their lansoprazole trial periods with significantly greater severity of heartburn and severity and frequency of acid regurgitation (P < 0.001). " 11/01/2013 - "NERD patients receiving dexlansoprazole 30 and 60 mg experienced significantly greater improvements in symptom severity for both heartburn and regurgitation compared with placebo. " 09/01/2009 - "Percentage of 24-h days without heartburn and percentage of subjects without heartburn on day 1 were significantly greater with lansoprazole 15 or 30 mg vs. placebo. "
4.	Infection 09/01/1996 - "4-day lansoprazole quadruple therapy: a highly effective cure for Helicobacter pylori infection." 09/01/1998 - "Lansoprazole quadruple therapy is effective in curing Helicobacter pylori infection." 05/01/1999 - "Efficacy of 7 day lansoprazole-based triple therapy for Helicobacter pylori infection in elderly patients." 11/01/2004 - "pylori infection, and to study the test performance after patients were treated with lanzoprazole, and after eradication therapy. " 08/01/2001 - "pylori infection, compared with a lansoprazole-based regimen, in a randomized multicentre study. "
5.	Ulcer 01/01/1991 - "AG-1749 raised the percentage of time with high pH to 99% from the 68% obtained with an H2RA and cured 88% of this type of ulcer. " 07/01/2011 - "Lansoprazole is effective in healing non-steroidal anti-inflammatory drugs induced ulcers, and antioxidant properties have been thought to play a key role in healing ulcers. " 10/15/2003 - "Lansoprazole reduces ulcer relapse after eradication of Helicobacter pylori in nonsteroidal anti-inflammatory drug users--a randomized trial." 07/01/1999 - "Within 1 month of study initiation, 27% (four out of 15) of placebo-treated patients experienced ulcer recurrence as compared to 13% (two out of 15) and 6% (one out of 18) of lansoprazole 15 mg and 30 mg treated patients, respectively. " 01/01/1995 - "In study II, the ulcer contraction rate after 8 weeks of treatment with lansoprazole was 71.8%, significantly higher than that achieved with H2-receptor antagonists. "

Related Drugs and Biologics

1.	Omeprazole (Esomeprazole)
2.	Ranitidine (Zantac)
3.	Amoxicillin (Wymox)
4.	Clarithromycin (Biaxin)
5.	Proton Pumps (Proton Pump)
6.	pantoprazole (Protonix)
7.	Proton Pump Inhibitors
8.	lansoprazole (Prevacid)
9.	Famotidine (Pepcid)
10.	rabeprazole (Aciphex)

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Fundoplication
3.	Drug-Eluting Stents
4.	Withholding Treatment
5.	Ligation