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thionapthene-2-carboxylic acid-lysine

potent antihypercalcemic agent

Also Known As:

TNLY; thionapthene-2-carboxylic acid lysine salt

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiophenes: 257
    - thionapthene-2-carboxylic acid-lysine: 1
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Thiophenes: 257
    - thionapthene-2-carboxylic acid-lysine: 1

Related Diseases

1.	Neoplasms (Cancer) 01/01/1989 - "The effects of thionapthene-2-carboxylic acid-lysine on the hypercalcemia of malignancy in the rat." 01/01/1989 - "In tumor-bearing rats that were not yet hypercalcemic, pretreatment with TNLY (0.9 mmol/kg/day) did not induce hypocalcemia and the onset of hypercalcemia was prevented. "
2.	Leydig Cell Tumor 01/01/1989 - "We have assessed thionapthene-2-carboxylic acid lysine salt (TNLY) for its effects on serum calcium concentration and survival in rats bearing the hypercalcemic Leydig cell tumor. "
3.	Hypocalcemia 01/01/1989 - "In tumor-bearing rats that were not yet hypercalcemic, pretreatment with TNLY (0.9 mmol/kg/day) did not induce hypocalcemia and the onset of hypercalcemia was prevented. "
4.	Hypercalcemia (Milk Alkali Syndrome) 01/01/1989 - "The effects of thionapthene-2-carboxylic acid-lysine on the hypercalcemia of malignancy in the rat." 01/01/1989 - "In tumor-bearing rats that were not yet hypercalcemic, pretreatment with TNLY (0.9 mmol/kg/day) did not induce hypocalcemia and the onset of hypercalcemia was prevented. "
5.	Bone Resorption 01/01/1989 - "Neither TNLY nor dichloromethylene diphosphonate (CL2MDP), a potent inhibitor of bone resorption, significantly prolonged overall survival. "

Related Drugs and Biologics

1.	thionapthene-2-carboxylic acid-lysine
2.	Clodronic Acid (Clodronate)
3.	Calcium