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pentamorphone

Also Known As:

RX 77989; RX-77989; RX77989; n-pentylaminomorphinone; Morphinan-6-one, 7,8-didehydro-4,5-epoxy-3-hydroxy-17-methyl-14-(pentylamino)-, (5alpha)-

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Related Diseases

1.	Pain (Aches) 05/01/1991 - "Only patients given 0.24 micrograms/kg of pentamorphone experienced decreased pain intensity and increased sedation, both transient in duration. " 03/01/1989 - "Pentamorphone produced a linear increase in pain tolerance with increasing dose as well as a dose-dependent depression of ventilation. "
2.	Postoperative Pain 05/01/1991 - "Pentamorphone (0.08-0.24 micrograms/kg) was ineffective for treating acute postoperative pain after major surgery." 05/01/1991 - "Pentamorphone for management of postoperative pain." 05/01/1991 - "The efficacy, duration, and safety of the synthetic opioid pentamorphone in the treatment of acute postoperative pain were evaluated in a randomized, double-blind study of 72 patients given 0.08, 0.16, or 0.24 micrograms/kg of pentamorphone or a placebo intravenously in the recovery room after major abdominal or orthopedic surgery. "
3.	Hypotension (Low Blood Pressure) 04/01/1992 - "When pentamorphone is used as the sole IV anesthetic in lorazepam-premedicated patients with normal or mildly impaired ventricular function, there is a high incidence of hypotension during induction, and poor control of hemodynamic responses to stimulation. "
4.	Hypertension (High Blood Pressure) 04/01/1992 - "Despite additional pentamorphone (total dose 9.6 +/- 1.8 micrograms/kg), 6 patients required thiopental and/or enflurane to control hypertension intraoperatively. "
5.	Hypercapnia 10/01/1990 - "Pentamorphone produced dose-related reductions in the ventilatory responses to both hypercapnia and hypoxia. " 10/01/1990 - "We quantified the effects of pentamorphone (0.08, 0.24, and 0.60 micrograms/kg, IV) on ventilatory responses to hypercapnia and hypoxia in 12 healthy volunteers. " 10/01/1990 - "Depression of ventilatory responses to hypoxia and hypercapnia after pentamorphone."

Related Drugs and Biologics

1.	Thiopental (Pentothal)
2.	Lorazepam (Ativan)
3.	Enflurane (Ethrane)
4.	Anesthetics (Anesthetic Agents)
5.	Opioid Analgesics (Opioids)

Related Therapies and Procedures

1.	Orthopedic Procedures