3-((aminoiminomethyl)thio)-2-propenoic acid (ZAPA)

potent agonist at GABA-receptors; RN given refers to (Z)-isomer; RN for cpd without isomeric designation not available 3/89

Also Known As:

ZAPA; 3-((aminoiminomethyl)thio)-2-propenoic acid monohydrobromide; 3-((aminoiminomethyl)thio)-2-propenoic acid monohydrochloride, (Z)-isomer; 3-((aminoiminomethyl)thio)-2-propenoic acid, (E)-isomer

Networked: 7 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Acyclic Acids
    - Acrylates: 212
      - 3-((aminoiminomethyl)thio)-2-propenoic acid: 7

Experts

1.	Ceri, Howard: 2 articles (10/2011 - 11/2008)
2.	Gilmore, Brendan F: 2 articles (10/2011 - 11/2008)
3.	Belas, Robert: 2 articles (11/2008 - 09/2004)
4.	Carson, Louise: 1 article (10/2011)
5.	Cathcart, George R: 1 article (10/2011)
6.	Hollenberg, Morley D: 1 article (10/2011)
7.	Scott, Christopher J: 1 article (10/2011)
8.	Walker, Brian: 1 article (10/2011)
9.	Dalbeth, Nicola: 1 article (06/2011)
10.	Doyle, Anthony: 1 article (06/2011)

Related Diseases

1.	Inflammation (Inflammations) 11/01/2008 - "Further, the ZapA(-) mutant failed to establish a chronic infection, in that bacteria were cleared from the prostate, inflammation was resolved, and tissue was seen to be healing. " 11/01/2008 - "Infection with the ZapA(-) mutant, however, resulted in reduced levels of acute prostatitis, as determined from lower levels of tissue damage, bacterial colonization, and inflammation. "
2.	Persistent Infection 11/01/2008 - "Further, the ZapA(-) mutant failed to establish a chronic infection, in that bacteria were cleared from the prostate, inflammation was resolved, and tissue was seen to be healing. "
3.	Psoriatic Arthritis 06/01/2011 - "Zoledronic acid does not reduce MRI erosive progression in PsA but may suppress bone oedema: the Zoledronic Acid in Psoriatic Arthritis (ZAPA) Study."
4.	Infections 01/01/2022 - "We present that ZapA protein is needed for phage inhibition by showing a phenotype recovery with a ZapA mutant strain, and we show that FtsI protein is also mislocalised upon phage infection. " 11/01/2008 - "Infection with the ZapA(-) mutant, however, resulted in reduced levels of acute prostatitis, as determined from lower levels of tissue damage, bacterial colonization, and inflammation. " 05/01/1999 - "ZapA- strains fail to degrade IgA and show decreased survival compared with the wild-type cells during infection in a mouse model of ascending urinary tract infection (UTI). " 10/01/2011 - "The most potent inactivator, SH-CO(2)-Y-V-NH(2) was capable of preventing ZapA-mediated hydrolysis of heat-denatured IgA, indicating that these inhibitors may be capable of protecting host proteins against ZapA during colonisation and infection."
5.	Urinary Tract Infections (Urinary Tract Infection) 09/01/2004 - "The data suggest that a function of ZapA during urinary tract infections is the proteolysis of antimicrobial peptides associated with the innate immune response." 05/01/1999 - "ZapA- strains fail to degrade IgA and show decreased survival compared with the wild-type cells during infection in a mouse model of ascending urinary tract infection (UTI). "

Related Drugs and Biologics

1.	Zoledronic Acid (Zometa)
2.	Proteins (Proteins, Gene)
3.	Immunoglobulin A (IgA)
4.	Metalloproteases (Metalloproteinases)
5.	Virulence Factors (Pathogenicity Factors)
6.	Vigabatrin
7.	Flurothyl (Flurotyl)
8.	Bicuculline
9.	4-Aminobutyrate Transaminase (4 Aminobutyrate Transaminase)
10.	Acids