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R 59949

diacylglycerol kinase inhibitor

Also Known As:

3-(2-(4-(bis(4-fluorophenyl)methylene)-1-piperdinyl)ethyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone; R 59 949; R-59949; R59949

Networked: 10 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperidines: 17
    - R 59949: 10
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinazolines: 402
      - Quinazolinones: 124
        R 59949: 10

Experts

1.	Harris, Thurl E: 2 articles (01/2017 - 07/2013)
2.	Purow, Benjamin W: 2 articles (01/2017 - 07/2013)
3.	Boroda, Salome: 1 article (01/2017)
4.	Niccum, Maria: 1 article (01/2017)
5.	Raje, Vidisha: 1 article (01/2017)
6.	Gao, Yi: 1 article (05/2015)
7.	Huang, Yongsheng: 1 article (05/2015)
8.	Li, Weihua: 1 article (05/2015)
9.	Liang, Xiaoling: 1 article (05/2015)
10.	Lu, Lin: 1 article (05/2015)

Related Diseases

1.	Hypoxia (Hypoxemia) 06/01/2010 - "Consistently, both siRNA-mediated downregulation of DGK theta and hepatocyte pretreatment with the DGK inhibitor R59949 induced cell tolerance to hypoxia. " 06/24/2005 - "We have previously shown that the hypoxia-induced accumulation of HIF-alpha protein is strongly impaired by the inhibitor of diacylglycerol kinase, R59949. " 11/15/2006 - "In addition, we show that hypoxia- and CoCl2-induced IL-8 expression requires activation of HIF as demonstrated by the following: 1) EMSA; 2) transfection studies with IL-8 promoter reporter constructs with mutation in HIF-1alpha binding site; 3) attenuation of IL-8 expression by both HIF-1alpha small interfering RNA and R59949; 4) augmentation of IL-8 expression by either transfection with HIF-prolyl hydroxylase-2 small interfering RNA or overexpression of HIF-1alpha; and 5) chromatin immunoprecipitation analysis. " 02/04/2011 - "Moreover, the effects of OAG, the DAG kinase inhibitor R59949 and the phospholipase C inhibitor U73122 on the strength of HPV were investigated compared to those on non-hypoxia-induced vasoconstriction elicited by the thromboxane mimeticum U46619. "
2.	Neoplasms (Cancer) 01/01/2017 - "Application of small-molecule DGK inhibitors, R59022 and R59949, induces cancer cell death in vitro and in vivo. " 07/01/2013 - "The attenuation of DGKα activity via DGKα-targeting siRNA and small-molecule inhibitors R59022 and R59949 induced caspase-mediated apoptosis in glioblastoma cells and in other cancers, but lacked toxicity in noncancerous cells. "
3.	Endometrial Neoplasms (Endometrial Cancer) 12/01/2011 - "Herein, using either specific siRNAs or the pharmacological inhibitor R59949, we demonstrate that DGK α activity is required for 17-β-estradiol (E2)-induced proliferation, motility, and anchorage-independent growth of Hec-1A endometrial cancer cell line. "
4.	Retinal Neovascularization 05/01/2015 - "Diacylglycerol kinase (DGK) inhibitor II (R59949) could suppress retinal neovascularization and protect retinal astrocytes in an oxygen-induced retinopathy model."
5.	Polyuria 05/01/2004 - "R59949 induced a potentiation of vasopressin-induced bradycardia in control animals compared with polyuria rats. "

Related Drugs and Biologics

1.	Small Interfering RNA (siRNA)
2.	Prolyl Hydroxylases (Prolyl Hydroxylase)
3.	Interleukin-8 (Interleukin 8)
4.	Chromatin
5.	Diacylglycerol Kinase
6.	R 59022
7.	Caspases
8.	15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
9.	Vasopressins (Vasopressin)
10.	Thromboxanes