isochorismate synthase

Formerly EC 5.4.99.6; catalyzes the reversible conversion of chorismate to isochorismate; do not confuse with SID2 protein

Also Known As:

Eds16 protein, Arabidopsis; ICS1 protein, Arabidopsis; ICS2 protein, S cerevisiae; SID2 protein, Arabidopsis; enhanced disease susceptibility 16 protein, Arabidopsis; isochorismate hydroxymutase; salicylic acid induction deficient 2 protein, Arabidopsis

Networked: 15 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Isomerases: 463
    - Intramolecular Transferases: 3
      - isochorismate synthase: 15

Experts

1.	Li, Xin: 2 articles (11/2018 - 10/2010)
2.	Zhang, Yuelin: 2 articles (11/2018 - 10/2010)
3.	Chen, Wenli: 1 article (07/2020)
4.	Gong, Wenjun: 1 article (07/2020)
5.	Li, Bingcong: 1 article (07/2020)
6.	Zhang, Baihong: 1 article (07/2020)
7.	Burketová, Lenka: 1 article (01/2020)
8.	Dobrev, I Petre: 1 article (01/2020)
9.	Guivarc'h, Anne: 1 article (01/2020)
10.	Janda, Martin: 1 article (01/2020)

Related Diseases

1.	Infections 10/18/2023 - "NbADR1, NbEDS1, and NbPAD4 are required for the pathogen infection-enhanced binding of NbWRKY40e to the ISOCHORISMATE SYNTHASE 1 promoter. " 12/03/2018 - "In Arabidopsis, SA is synthesized from chorismate in the chloroplast through the ICS1 (isochorismate synthase I) pathway during pathogen infection. " 10/01/2016 - "Real-time monitored expression of a gene for isochorismate synthase was induced on infection. " 10/19/2010 - "Pathogen infections induce SA synthesis through up-regulating the expression of Isochorismate Synthase 1 (ICS1), which encodes a key enzyme in SA production. " 12/01/2017 - "GhPGIP1 overexpression in transgenic Arabidopsis conferred resistance to the infection, accompanied by enhanced expression of pathogenesis-related proteins (PRs), isochorismate synthase 1 (ICS1), enhanced disease susceptibility 1 (EDS1), and phytoalexin-deficient 4 (PAD4) genes. "
2.	Disease Susceptibility (Diathesis) 07/01/2023 - "Furthermore, transcriptional analysis revealed that genes involved in SA biosynthesis, such as ISOCHORISMATE SYNTHASE 1 (SlICS1) and ENHANCED DISEASE SUSCEPTIBILITY 5 (SlEDS5), were upregulated in slnrx1 compared to WT plants. " 01/01/2018 - "The mechanism for decoding calcium signatures to control expression of plant immunity genes enhanced disease susceptibility 1 (EDS1) and isochorismate synthase 1 (ICS1) was identified. " 08/01/2015 - "A comparative analysis of two SA synthesis pathways in Arabidopsis revealed that SA concentration mainly increased via the isochorismate synthase 1 (ICS1)-mediated isochorismate pathway, which depended on essential regulative function of enhanced disease susceptibility 1 (EDS1). " 06/01/2013 - "The defense response mediated by AGB1 is independent of pathogen-dependent salicylic acid accumulation and signaling, as the agb1 sid2 (isochorismate synthase 2) double mutant showed enhanced disease susceptibility to P. " 12/01/2017 - "GhPGIP1 overexpression in transgenic Arabidopsis conferred resistance to the infection, accompanied by enhanced expression of pathogenesis-related proteins (PRs), isochorismate synthase 1 (ICS1), enhanced disease susceptibility 1 (EDS1), and phytoalexin-deficient 4 (PAD4) genes. "
3.	Virus Diseases (Viral Diseases) 01/01/2017 - "A key enzyme for SA biosynthesis is isochorismate synthase (ICS), which converts chorismate into isochorismate, and for which there are two genes in Arabidopsis thaliana One (AtICS1) has been shown to be required for increased SA biosynthesis in response to pathogens and its expression can be stimulated throughout the leaf by virus infection and exogenous SA. "
4.	Dwarfism 01/01/2020 - "By crossing this pi4kβ1β2 double mutant with mutants impaired in SA synthesis (such as sid2 impaired in isochorismate synthase) or transduction, we demonstrated that the high SA level was responsible for the dwarfism phenotype of the double mutant. "
5.	Iron Deficiencies 04/01/1996 - "The metabolic shift from one diene to the other is caused by a change in activity of isochorismate hydroxymutase and/or isochorismatase which in turn results from growth under iron deficiency or overexpression of genes (entC and/or entB) involved in chrismate metabolism."

Related Drugs and Biologics

1.	Salicylic Acid (2 Hydroxybenzoic Acid)
2.	Proteins (Proteins, Gene)
3.	Enzymes
4.	isochorismic acid (isochorismate)
5.	Transcription Factors (Transcription Factor)
6.	Glucosyltransferases
7.	Carrier Proteins (Binding Protein)
8.	Calmodulin (Calcium-Dependent Activator Protein)
9.	Calcium
10.	isochorismatase