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N- (2'- (dimethylamino)ethyl)acridine- 4- carboxamide
Also Known As:
DACA-N; N-(2-(dimethylamino)ethyl)acridine-4-carboxamide; NSC 601316; NSC-601316; 4-Acridinecarboxamide, N-(2-(dimethylamino)ethyl)-
Networked:
5
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
3-Ring Heterocyclic Compounds
Acridines: 325
N-(2'-(dimethylamino)ethyl)acridine-4-carboxamide: 5
Related Diseases
1.
Lewis Lung Carcinoma
01/01/1990 - "
(N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide (acridine carboxamide; NSC 601316) is an acridine-derived experimental antitumour agent with curative properties against Lewis lung carcinoma in mice.
"
11/01/1988 - "
N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide (NSC 601316) is a DNA intercalating experimental antitumour agent which is curative against the Lewis lung carcinoma in mice.
"
2.
Poisoning
04/01/1996 - "
A number of acridine derivatives, including the clinical antileukaemia agent amsacrine and the experimental agent DACA (N-[2-(dimethylamino)ethyl]acridine-4-carboxamide), target the enzyme topoisomerase II. We demonstrate here that DACA induces DNA cleavage in the presence of topoisomerase I as well as of topoisomerase II. We also investigate a series of acridine derivatives which link amsacrine to DACA in terms of DNA binding, topoisomerase poisoning and biological activity.
"
3.
Neoplasms (Cancer)
01/01/1993 - "
These agents comprised amsacrine, CI-921 (9-[(2-methoxy-4-methylsulfonylamino)phenylamino]-N,5-dimethyl-4- acridinecarboxamide isethionate, isethionate, a derivative of amsacrine), DACA (N-[2-(dimethylamino)ethyl]acridine-4-carboxamide dihydrochloride, a new DNA intercalator with high solid tumor activity), daunorubicin, doxorubicin, epirubicin, etoposide, mitoxantrone, and teniposide.
"
4.
Carcinoma (Carcinomatosis)
01/01/1999 - "
We show here that drug molecules such as N-phenylmethanesulfonamide, which mimic the anilino side chain of amsacrine, inhibit the cytotoxicity against cultured Lewis lung murine carcinoma of amsacrine, amsacrine analogues including asulacrine and DACA (N-[2-(dimethylamino)-ethyl]acridine-4-carboxamide dihydrochloride), and etoposide.
"
Related Drugs and Biologics
1.
Acridines
2.
Amsacrine (AMSA)
3.
Etoposide (VP 16)
4.
DNA (Deoxyribonucleic Acid)
5.
asulacrine
6.
A-Form DNA (A-DNA)
7.
Epirubicin (Ellence)
8.
Teniposide (VM 26)
9.
Mitoxantrone (Novantrone)
10.
Intercalating Agents