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N- (2'- (dimethylamino)ethyl)acridine- 4- carboxamide

Also Known As:

DACA-N; N-(2-(dimethylamino)ethyl)acridine-4-carboxamide; NSC 601316; NSC-601316; 4-Acridinecarboxamide, N-(2-(dimethylamino)ethyl)-

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Acridines: 325
      - N-(2'-(dimethylamino)ethyl)acridine-4-carboxamide: 5

Related Diseases

1.	Lewis Lung Carcinoma 01/01/1990 - "(N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide (acridine carboxamide; NSC 601316) is an acridine-derived experimental antitumour agent with curative properties against Lewis lung carcinoma in mice. " 11/01/1988 - "N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide (NSC 601316) is a DNA intercalating experimental antitumour agent which is curative against the Lewis lung carcinoma in mice. "
2.	Poisoning 04/01/1996 - "A number of acridine derivatives, including the clinical antileukaemia agent amsacrine and the experimental agent DACA (N-[2-(dimethylamino)ethyl]acridine-4-carboxamide), target the enzyme topoisomerase II. We demonstrate here that DACA induces DNA cleavage in the presence of topoisomerase I as well as of topoisomerase II. We also investigate a series of acridine derivatives which link amsacrine to DACA in terms of DNA binding, topoisomerase poisoning and biological activity. "
3.	Neoplasms (Cancer) 01/01/1993 - "These agents comprised amsacrine, CI-921 (9-[(2-methoxy-4-methylsulfonylamino)phenylamino]-N,5-dimethyl-4- acridinecarboxamide isethionate, isethionate, a derivative of amsacrine), DACA (N-[2-(dimethylamino)ethyl]acridine-4-carboxamide dihydrochloride, a new DNA intercalator with high solid tumor activity), daunorubicin, doxorubicin, epirubicin, etoposide, mitoxantrone, and teniposide. "
4.	Carcinoma (Carcinomatosis) 01/01/1999 - "We show here that drug molecules such as N-phenylmethanesulfonamide, which mimic the anilino side chain of amsacrine, inhibit the cytotoxicity against cultured Lewis lung murine carcinoma of amsacrine, amsacrine analogues including asulacrine and DACA (N-[2-(dimethylamino)-ethyl]acridine-4-carboxamide dihydrochloride), and etoposide. "

Related Drugs and Biologics

1.	Acridines
2.	Amsacrine (AMSA)
3.	Etoposide (VP 16)
4.	DNA (Deoxyribonucleic Acid)
5.	asulacrine
6.	A-Form DNA (A-DNA)
7.	Epirubicin (Ellence)
8.	Teniposide (VM 26)
9.	Mitoxantrone (Novantrone)
10.	Intercalating Agents