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indospicine

RN given refers to (S)-isomer

Also Known As:

6-amidino-2-aminohexanoic acid; indospicine, (+-)-isomer

Networked: 11 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Aminocaproates: 1
    - Norleucine: 30
      - indospicine: 11

Experts

1.	Fletcher, Mary T: 5 articles (03/2021 - 02/2014)
2.	Al Jassim, Rafat: 3 articles (10/2016 - 02/2014)
3.	D'Arcy, Bruce R: 3 articles (10/2016 - 02/2014)
4.	Tan, Eddie T T: 3 articles (10/2016 - 02/2014)
5.	Bobak, Yaroslav P: 1 article (03/2021)
6.	Kunz-Schughart, Leoni A: 1 article (03/2021)
7.	Shuvayeva, Galyna Y: 1 article (03/2021)
8.	Stasyk, Oleh V: 1 article (03/2021)
9.	Vovk, Olena I: 1 article (03/2021)
10.	Addepalli, Rama: 1 article (11/2018)

Related Diseases

1.	Hepatocellular Carcinoma (Hepatoma) 11/30/2018 - "In this study three human cell lines, Caco-2 (colorectal adenocarcinoma), HT29-MTX-E12 (colorectal adenocarcinoma) and HepG2 (hepatocellular carcinoma), were used to investigate the cytotoxicity of indospicine and its metabolite 2-aminopimelic acid in comparison to arginine. " 09/01/1978 - "3. Labile protein was produced in hepatoma cells incubated in the presence of azetidine-2-carboxylic acid, canavanine, indospicine, triazolalanine, 2-, 3- and 4-fluorophenylalanine. "
2.	Adenocarcinoma 11/30/2018 - "In this study three human cell lines, Caco-2 (colorectal adenocarcinoma), HT29-MTX-E12 (colorectal adenocarcinoma) and HepG2 (hepatocellular carcinoma), were used to investigate the cytotoxicity of indospicine and its metabolite 2-aminopimelic acid in comparison to arginine. "
3.	Poisoning 08/31/2016 - "The secondary poisoning of dogs after prolonged dietary exposure to residual indospicine in camel muscle has raised additional food safety concerns. " 02/26/2014 - "Dogs are particularly sensitive to indospicine, and secondary poisoning of dogs has occurred from the ingestion of indospicine-contaminated horse meat and more recently camel meat. " 09/01/2012 - "Based on the preponderance of indospince and lack of nitro toxins in the samples it is proposed that indospicine is the toxic compound responsible for the poisoning."
4.	Liver Diseases (Liver Disease) 10/01/2022 - "Between June and September 2021, 24 pet dogs died, and 40 others experienced liver disease after eating commercially prepared pet meat found to contain indospicine. " 10/01/2022 - "Dogs are particularly sensitive to indospicine toxicity and can suffer fatal liver disease after eating indospicine-contaminated pet meat. " 03/01/2011 - "To the authors' knowledge, this is the first published report of the detection of indospicine residues in camel meat and the occurrence of severe, sometimes fatal, liver disease in dogs that consumed this contaminated meat." 10/01/2016 - "This camel meat was found to contain residues of indospicine, a non-proteinogenic amino acid found in certain Indigofera spp., and associated with mild to severe liver disease in diverse animals after dietary exposure to this hepatotoxin. "
5.	Colorectal Neoplasms (Colorectal Cancer) 03/01/2021 - "In this report, we evaluated for the first time indospicine, an arginine analogue of Indigofera plant genus origin, as potential enhancer compound for the metabolic therapy that utilizes recombinant human arginase I. We demonstrate that indospicine at low micromolar concentrations is selectively toxic for human colorectal cancer cells only in the absence of arginine. "

Related Drugs and Biologics

1.	Arginine (L-Arginine)
2.	alpha-aminopimelic acid
3.	TOR Serine-Threonine Kinases
4.	Proteins (Proteins, Gene)
5.	p-Fluorophenylalanine
6.	Canavanine
7.	Azetidinecarboxylic Acid
8.	Arginase
9.	Amino Acids

Related Therapies and Procedures

1.	Therapeutics