phenethyl isothiocyanate (PEITC)

12/01/2014 - "Pre-clinical evidence suggests that combination of PEITC with conventional anti-cancer agents is also highly effective in improving overall efficacy. "
07/01/2002 - "Thus, it seems reasonable to postulate that PEITC may be effective against tumors with normal as well as mutant p53."
01/01/2014 - "PEITC manifested protection against chemically-induced cancers in various tissues. "
04/08/2015 - "Moreover, studies in cell culture and in animals found that the anticarcinogenic activities of PEITC involved all the major stages of tumor growth: initiation, promotion, and progression. "
06/01/2013 - "This study represents the first use of RNAseq to analyze tumors from animals consuming dietary phenethyl isothiocyanate and to identify potential molecular signatures that may explain the cancer protective effect of this compound."

01/01/2014 - "Human prostate cancer LNCaP cells were exposed to PEITC and the effects on cellular fine structure examined by transmission electron microscopic studies. "
05/01/2011 - "This study showed that PEITC might exhibit anticancer activity and become a potent agent for human prostate cancer cells in the future."
01/01/2009 - "Flow cytometry, light microscopy and western blot were used to study the cell cycle distribution, morphology changes and the expression of alpha- and beta-tubulins in prostate cancer cells treated with PEITC. "
01/01/2014 - "Mitochondrial structure alteration in human prostate cancer cells upon initial interaction with a chemopreventive agent phenethyl isothiocyanate."
07/01/2012 - "Phenethyl isothiocyanate suppresses inhibitor of apoptosis family protein expression in prostate cancer cells in culture and in vivo."

12/01/2000 - "These findings provide important laboratory evidence for a potential role of SFN and PEITC in the protection against colon cancer."
10/27/2010 - "Here, in this study, we are the first to report the antimetastatic effect of PEITC in HT29 human colon cancer cells. "
10/27/2010 - "In the primary studies, we found that PEITC induced cytotoxic effect (decreased the percentage of viable cells) in human colon cancer HT29 cells. "
06/01/2008 - "In the present study, we investigate the effect of PEITC on cell cycle regulation of HT-29 colon cancer cells. "
07/14/2005 - "The current study was undertaken to determine the effects of H(2)S on PEITC mediated apoptosis in colon cancer cells. "

01/01/2016 - "Finally, our study demonstrated that modulation of HIF-1α by PEITC retarded adhesion, aggregation, migration and invasion of the breast cancer cells, thereby showing anti-metastatic effect. "
01/01/2016 - "Phenethyl isothiocyanate, by virtue of its antioxidant activity, inhibits invasiveness and metastatic potential of breast cancer cells: HIF-1α as a putative target."
07/01/2014 - "Inhibition of angiogenesis is one of the recently reported mechanisms of breast cancer prevention by PEITC. "
07/01/2014 - "Pharmacokinetics and pharmacodynamics of phenethyl isothiocyanate: implications in breast cancer prevention."
03/01/2013 - "For the first time, it is reported that PEITC has anti-angiogenic effects in a chemically induced breast cancer animal model, representing a potentially significant mechanism contributing to its chemopreventive activity."

01/01/2010 - "In the present study, we investigated the inhibitory effects of BITC and PEITC on metastatic potential of highly metastatic human lung cancer L9981 cells. "
12/01/1995 - "The results of this study support our hypothesis that PEITC inhibits this oxidative metabolism of NNK in humans, as seen in rodents, and support further development of PEITC as a chemopreventive agent against lung cancer. "
10/01/2012 - "Phenethyl isothiocyanate-induced cytoskeletal changes and cell death in lung cancer cells."
07/01/1992 - "These results implicate dietary PEITC as a risk-reducing factor of lung cancers induced by smoking. "
05/01/1992 - "Considering the anticarcinogenic activity of phenethyl isothiocyanate, this marker may eventually be useful in assessing the role of dietary phenethyl isothiocyanate uptake in lung cancer risk."