HOME
PRODUCTS
COMPANY
CONTACT
FAQ
Research
Dictionary
Pharma
Sign Up
FREE
or
Login
Username:
Password:
Remember login
Login
Send password reminder...
MDL 27695
structure given in first source
Also Known As:
MDL-27695; N,N'-bis(3-((phenylmethyl)amino)propyl)-1,7-diaminoheptane; 1,7-Heptanediamine, N,N'-bis(3-((phenylmethyl)amino)propyl)-
Networked:
3
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amines: 4871
Polyamines: 3918
MDL 27695: 3
Related Diseases
1.
Neoplasms (Cancer)
01/01/1997 - "
Our studies also showed that MDL 27695, at a dose of 20 mg/kg, caused a significant inhibition of tumor growth in nude mice harboring MCF-7 cell derived tumors, without overt symptoms of toxicity.
"
2.
Hepatocellular Carcinoma (Hepatoma)
02/01/1989 - "
A bisbenzyl polyamine analogue, MDL 27695, rapidly repressed ornithine decarboxylase (ODC) and S-adenosyl-L-methionine decarboxylase (AdoMet DC) activity and depleted polyamines in rat hepatoma (HTC) cells.
"
3.
Breast Neoplasms (Breast Cancer)
01/01/1997 - "
These data indicate that the polyamine analog MDL 27695 is an efficient inhibitor of MCF-7 breast cancer cell growth in vitro and in vivo.
"
01/01/1997 - "
We studied the effects of a polyamine analog, N,N'-bis{3-[(phenylmethyl)amino]propyl}-1,7-diaminoheptane (MDL 27695) on MCF-7 cells, as part of an attempt to develop new drugs for breast cancer treatment.
"
4.
Body Weight (Weight, Body)
12/01/1993 - "
donovani infected hamsters when treated three times per day for 4 days with a total dose of 60 mg kg-1 body weight of MDL 27695.
"
Related Drugs and Biologics
1.
Polyamines
2.
S-Adenosylmethionine (Ademetionine)
3.
Ornithine Decarboxylase (Decarboxylase, Ornithine)
4.
Carboxy-Lyases