aspartic acid 2-oxoglutarate-dependent dioxygenase

hydroxylates one aspartic acid residue in the first EGF-like unit of factor IX; BAH humbug is a noncatalytic isoform

Also Known As:

Asp-2-OG-dioxygenase; aspartate 2-oxoglutarate dioxygenase; aspartyl (asparaginyl) beta-hydroxylase; aspartyl beta-hydroxylase; aspartyl-asparaginyl beta-hydroxylase; humbug gene product, human

Networked: 26 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Oxygenases: 333
      - Mixed Function Oxygenases: 2175
        aspartic acid 2-oxoglutarate-dependent dioxygenase: 26

Experts

1.	Wands, Jack R: 11 articles (09/2010 - 07/2002)
2.	de la Monte, Suzanne M: 11 articles (09/2010 - 07/2002)
3.	Maeda, Takashi: 4 articles (05/2006 - 07/2002)
4.	Yang, Hui: 3 articles (01/2015 - 02/2010)
5.	Carlson, Rolf I: 3 articles (05/2009 - 07/2002)
6.	Carter, Jade J: 3 articles (05/2009 - 05/2006)
7.	Lahousse, Stephanie A: 3 articles (12/2006 - 07/2002)
8.	Huyan, Ting: 2 articles (04/2011 - 02/2010)
9.	Song, Kai: 2 articles (04/2011 - 02/2010)
10.	Wang, Wei: 2 articles (04/2011 - 02/2010)

Related Diseases

1.	Hepatocellular Carcinoma (Hepatoma) 02/01/2006 - "The purpose of this study was to investigate the expression of aspartyl beta-hydroxylase in hepatocellular carcinoma. " 07/01/2010 - "The association between the overexpression of aspartyl-(asparaginyl)-beta-hydroxylase (AAH) and the invasiveness of hepatocellular carcinoma (HCC) in vitro has been reported. " 07/01/2010 - "Overexpression of aspartyl-(asparaginyl)-beta-hydroxylase in hepatocellular carcinoma is associated with worse surgical outcome." 08/01/2009 - "We newly cloned the gene encoding the human aspartyl (asparaginyl) beta-hydroxylase (HAAH) from the surgical tissue of a patient with hepatocellular carcinoma. " 05/01/2006 - "Aspartyl-(asparaginyl)-beta-hydroxylase regulates hepatocellular carcinoma invasiveness."
2.	Carcinoma (Carcinomatosis) 01/01/2015 - "The aspartyl (asparaginyl) beta-hydroxylase in carcinomas." 05/01/2009 - "Previous studies showed that increased levels of aspartyl (asparaginyl)-beta-hydroxylase and a highly related molecule, humbug, correlate with clinical course and survival with hepatic, biliary, pancreatic, and colon carcinomas. " 05/01/2006 - "We measured aspartyl (asparaginyl)-beta-hydroxylase (AAH) gene expression in human hepatocelluar carcinoma and surrounding uninvolved liver at both the mRNA and protein level and examined the regulation and function of this enzyme. "
3.	Disease Progression 05/01/2009 - "Previous studies showed that increased levels of aspartyl (asparaginyl)-beta-hydroxylase and a highly related molecule, humbug, correlate with clinical course and survival with hepatic, biliary, pancreatic, and colon carcinomas. "
4.	Neoplasms (Cancer) 04/01/2011 - "We investigated the mechanism of human aspartyl beta-hydroxylase (HAAH) in early diagnosis of tumors. " 02/01/2010 - "To evaluate the distribution and expression profile of Aspartyl/Asparaginyl beta-hydroxylase, ASPH in some tumor cell lines and tumor tissues. " 09/01/2007 - "Aspartyl (asparaginyl) beta-hydroxylase and humbug are overexpressed in a broad range of malignant neoplasms. " 02/01/2006 - "The aspartyl beta-hydroxylase gene is upregulated in many human malignancies. " 07/01/2002 - "Aspartyl (asparaginyl) beta-hydroxylase (AAH) is overexpressed in various malignant neoplasms, and high levels of immunoreactivity mainly occur in infiltrating or metastasized tumors. "
5.	Cholangiocarcinoma 01/01/2004 - "Clinicopathological correlates of aspartyl (asparaginyl) beta-hydroxylase over-expression in cholangiocarcinoma." 01/01/2004 - "Aspartyl (asparaginyl) beta-hydroxylase (AAH) expression in surgically resected intrahepatic cholangiocarcinoma significantly correlated with tumor size, growth type, differentiation, vascular invasion, and prognosis after surgery. " 09/15/1996 - "Overexpression of human aspartyl(asparaginyl)beta-hydroxylase in hepatocellular carcinoma and cholangiocarcinoma." 05/01/2003 - "Antisense oligodeoxynucleotides directed against aspartyl (asparaginyl) beta-hydroxylase suppress migration of cholangiocarcinoma cells." 01/01/2007 - "Overexpression of aspartyl (asparaginyl) beta-hydroxylase (AAH) has been demonstrated in hepatocellular carcinoma, cholangiocarcinoma, and pancreatic carcinoma. "

Related Drugs and Biologics

1.	Messenger RNA (mRNA)
2.	Proteins (Proteins, Gene)
3.	Enzymes
4.	Antigens
5.	Monoclonal Antibodies
6.	Intercellular Signaling Peptides and Proteins (Growth Factors)
7.	Protein Isoforms (Isoforms)
8.	Complementary DNA (cDNA)
9.	Antisense Oligonucleotides
10.	Biomarkers (Surrogate Marker)