1,7- (dioxa)- 2,6- diaza- 4,7a- dithia- 3H,5H- benzo(cd)pentalene- 4- oxide

structure given in first source; mediates superoxide & hydrogen peroxide production in E coli

Also Known As:

HEP-III

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Inorganic Chemicals: 9
- Nitrogen Compounds: 67
  - Azides: 384
    - 1,7-(dioxa)-2,6-diaza-4,7a-dithia-3H,5H-benzo(cd)pentalene-4-oxide: 3
Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Cyclopentanes: 58
        1,7-(dioxa)-2,6-diaza-4,7a-dithia-3H,5H-benzo(cd)pentalene-4-oxide: 3
- Azides: 384
  - 1,7-(dioxa)-2,6-diaza-4,7a-dithia-3H,5H-benzo(cd)pentalene-4-oxide: 3

Experts

1.	Georgopoulos, Angelique: 1 article (04/2002)
2.	Kitsiou, Paraskevi V: 1 article (04/2002)
3.	Talamagas, Argiris A: 1 article (04/2002)
4.	Tsilibary, Effie C: 1 article (04/2002)
5.	Tzinia, Athina K: 1 article (04/2002)
6.	Anderson, C J: 1 article (11/2001)
7.	Edwards, W B: 1 article (11/2001)
8.	Fields, G B: 1 article (11/2001)
9.	Welch, M J: 1 article (11/2001)

Related Diseases

1.	Neoplasms (Cancer) 11/01/2001 - "Heterologous competitive binding assays between D-Hep-III and either 125I-D-Hep-III or 64Cu-TETA-D-Hep-III indicated low micromolar affinity of D-Hep-III. The biodistribution of each radiolabeled analogue of D-Hep-III was carried out in rats and tumor-bearing mice. " 11/01/2001 - "Localization of 125I-D-Hep III and 64Cu-TETA-D-Hep III in the xenografts were low (<2% ID/g), and in the case of 125I-D-Hep III, not inhibited by a competitive dose of D-Hep III. The low tumor accumulation is likely not due to receptor down-regulation, but rather due to the weak affinity of the radioligands for the alpha3beta1 integrin." 12/09/1997 - "Among these regions, the alpha1(IV)531-543 sequence, designated L-Hep-III, promotes integrin-mediated tumor cell adhesion and directly binds to the alpha3beta1 integrin [Miles, A. " 12/09/1997 - "D-Hep-III is the first all-D peptide that has been shown to promote tumor cell adhesion, spreading, and migration, inhibit tumor cell adhesion and migration on type IV collagen and invasion of the basement membrane, and bind directly to an integrin. "
2.	Neuroblastoma 04/01/2002 - "By adhesion assays we demonstrated that neuroblastoma cells bound to solid-phase intact collagen IV and synthetic cell-binding peptide HEP-III, derived from the collagenous part of the molecule, but not to the main noncollagenous NC1 domain or to the synthetic cell-binding peptide HEP-I, derived from this domain. "
3.	Melanoma (Melanoma, Malignant) 12/09/1997 - "We have presently compared the activities of the all-d enantiomeric peptide model of alpha1(IV)531-543, designated D-Hep-III, with L-Hep-III, for promoting the adhesion, spreading, and motility of metastatic melanoma and breast carcinoma cells. " 12/09/1997 - "D-Hep-III was found to support melanoma and breast carcinoma cell adhesion, spreading, and motility in a dose-dependent fashion similar to that of L-Hep-III. The adhesions of melanoma and breast carcinoma cells to both type IV collagen and fibronectin were effectively inhibited by L-Hep-III and D-Hep-III. Melanoma cell invasion of the basement membrane was also inhibited by D-Hep-III. Characterization of the cell surface receptor for D-Hep-III was acheived via cell adhesion assays and affinity chromatography using monoclonal antibodies against integrin subunits. "
4.	Breast Neoplasms (Breast Cancer) 12/09/1997 - "We have presently compared the activities of the all-d enantiomeric peptide model of alpha1(IV)531-543, designated D-Hep-III, with L-Hep-III, for promoting the adhesion, spreading, and motility of metastatic melanoma and breast carcinoma cells. " 12/09/1997 - "D-Hep-III was found to support melanoma and breast carcinoma cell adhesion, spreading, and motility in a dose-dependent fashion similar to that of L-Hep-III. The adhesions of melanoma and breast carcinoma cells to both type IV collagen and fibronectin were effectively inhibited by L-Hep-III and D-Hep-III. Melanoma cell invasion of the basement membrane was also inhibited by D-Hep-III. Characterization of the cell surface receptor for D-Hep-III was acheived via cell adhesion assays and affinity chromatography using monoclonal antibodies against integrin subunits. "

Related Drugs and Biologics

1.	Integrin alpha3beta1
2.	Peptides (Polypeptides)
3.	Collagen Type IV (Type IV Collagen)
4.	Integrins
5.	Cell Surface Receptors
6.	Fibronectins (Fibronectin)
7.	Collagen
8.	Monoclonal Antibodies
9.	4,4- dimethyl- 1,7- dioxa- 2,6- diaza- 7a- thia- 3H,5H- benzo(cd)pentalene