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4,4- dimethyl- 1,7- dioxa- 2,6- diaza- 7a- thia- 3H,5H- benzo(cd)pentalene

structure given in first source; mediates superoxide & hydrogen peroxide production in E coli

Also Known As:

HEP-I

Networked: 8 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Inorganic Chemicals: 9
- Nitrogen Compounds: 67
  - Azides: 384
    - 4,4-dimethyl-1,7-dioxa-2,6-diaza-7a-thia-3H,5H-benzo(cd)pentalene: 8
Organic Chemicals: 133
- Azides: 384
  - 4,4-dimethyl-1,7-dioxa-2,6-diaza-7a-thia-3H,5H-benzo(cd)pentalene: 8

Experts

1.	Arnolds, Oliver: 1 article (10/2018)
2.	Gajewski, Jana: 1 article (10/2018)
3.	Herrmann, Christian: 1 article (10/2018)
4.	Krenczyk, Oktavian: 1 article (10/2018)
5.	Pütz, Stefanie: 1 article (10/2018)
6.	Stoll, Raphael: 1 article (10/2018)
7.	Zhong, Xueyin: 1 article (10/2018)
8.	Hirneiß, Christoph: 1 article (07/2015)
9.	Kampik, Anselm: 1 article (07/2015)
10.	Lamparter, Julia: 1 article (07/2015)

Related Diseases

1.	Neuroblastoma 04/01/2002 - "By adhesion assays we demonstrated that neuroblastoma cells bound to solid-phase intact collagen IV and synthetic cell-binding peptide HEP-III, derived from the collagenous part of the molecule, but not to the main noncollagenous NC1 domain or to the synthetic cell-binding peptide HEP-I, derived from this domain. " 10/23/2018 - "Fibronectin is a large multidomain protein of the extracellular matrix that harbors two heparin binding sites, Hep-I and Hep-II, which support the heparin-dependent adhesion of melanoma and neuroblastoma cells [Barkalow, F. "
2.	Pain (Aches) 01/01/2023 - "Qualitative analysis revealed the following themes associated with adherence to a HEP: (i) prior PT, (ii) observability of outcomes, (iii) expectations of PT, and (iv) experience of pain. "
3.	Ocular Hypertension (Glaucoma, Suspect) 07/01/2015 - "The FDF was abnormal in 21.7% in the control group compared to 58.5% in the glaucoma suspect group in HEP I. In more than half of the patients with ONHs or RNFLs clinically suspicious for glaucoma and normal SAP second FDF perimetry depicts VF defects."
4.	Melanoma (Melanoma, Malignant) 10/23/2018 - "Fibronectin is a large multidomain protein of the extracellular matrix that harbors two heparin binding sites, Hep-I and Hep-II, which support the heparin-dependent adhesion of melanoma and neuroblastoma cells [Barkalow, F. "
5.	Ischemia 09/27/2022 - "Hepatic ischemia-reperfusion (Hep I/R) takes place clinically during different scenarios of liver pathologies. "

Related Drugs and Biologics

1.	1,7- dioxa- 2,6- diaza- 4,7a- dithia- 3H,5H- benzo(cd)pentalene
2.	Proteins (Proteins, Gene)
3.	Peptides (Polypeptides)
4.	Interleukin-1 (Interleukin 1)
5.	Heparin (Liquaemin)
6.	Fibronectins (Fibronectin)
7.	Collagen
8.	1,7- (dioxa)- 2,6- diaza- 4,7a- dithia- 3H,5H- benzo(cd)pentalene- 4- oxide
9.	sodium chlorate
10.	heparitinsulfate lyase