insect defensin A

MW 4 kDa; 40 amino acid residues given in first source; from Phormia terranovae

Also Known As:

AaeDefA5; defensin A

Networked: 9 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Pore Forming Cytotoxic Proteins
      - Antimicrobial Cationic Peptides: 414
        Defensins: 1422
        insect defensin A: 9
- Peptides: 82426
  - Antimicrobial Peptides: 3727
    - Antimicrobial Cationic Peptides: 414
      - Defensins: 1422
        insect defensin A: 9
  - Antimicrobial Cationic Peptides: 414
    - Defensins: 1422
      - insect defensin A: 9

Experts

1.	Kokoza, Vladimir: 2 articles (05/2010 - 04/2009)
2.	Raikhel, Alexander S: 2 articles (05/2010 - 04/2009)
3.	Jiménez-Alcántar, Paola: 1 article (01/2022)
4.	López-Gómez, Rodolfo: 1 article (01/2022)
5.	López-Meza, Joel E: 1 article (01/2022)
6.	Ochoa-Zarzosa, Alejandra: 1 article (01/2022)
7.	Bahia, Ana Cristina: 1 article (01/2021)
8.	Bombaça, Ana Cristina S: 1 article (01/2021)
9.	Bottino-Rojas, Vanessa: 1 article (01/2021)
10.	Bruno, Rafaela V: 1 article (01/2021)

Related Diseases

1.	Infections 01/01/2021 - "The presence of these parasites induced specific transcriptional modulation of immune-related genes, such as attacin and defensin A during WTR infection (11.8- and 6.4-fold, respectively) and defensin C in WT infection (7.1-fold). " 01/01/2021 - "Inhibition of defensin A and cecropin A responses to dengue virus 1 infection in Aedes aegypti." 04/01/2009 - "Consistently, RNAi knockdown of REL2 in wild-type mosquitoes results in a delay in Defensin A and Cecropin A expression in response to infection and in increased susceptibility to both bacteria and P. " 01/17/2023 - "At 24 h, cathepsin B was upregulated by infection with conidia, whereas both propagules resulted in a downregulation of cecropin and defensin A. "
2.	Wounds and Injuries (Trauma) 11/01/1997 - "Defensin A is an inducible cationic protein secreted in the hemolymph of fleshfly Phormia terranovae larvae in response to bacterial or septic injuries. " 05/15/1995 - "Insect defensin A is a basic 4 kDa protein secreted by Phormia terranovae larvae in response to bacterial challenges or injuries. "
3.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/01/2022 - "In this work, we show that the PaDef defensin, a plant antimicrobial peptide from Mexican avocado fruit (Persea americana var. drymifolia) is cytotoxic for Jurkat cell line from acute lymphoid leukemia cells, through an apoptotic process. "
4.	Virus Diseases (Viral Diseases) 03/14/2020 - "Finally, the assay was used with success to detect both ZIKV RNA in infected mosquitoes and to detect expression of the Defensin A gene, an antimicrobial peptide (AMP) involved in Aedes aegypti immune response to virus infection. "
5.	Pseudomonas Infections 05/04/2010 - "The transgenic hybrid mosquitoes that overexpressed both Cecropin A and Defensin A under the control of the vitellogenin promoter exhibited an elevated resistance to Pseudomonas aeruginosa infection, indicating that these AMPs acted cooperatively against this pathogenic bacterium. "

Related Drugs and Biologics

1.	cecropin A
2.	Proteins (Proteins, Gene)
3.	Antimicrobial Peptides
4.	Cecropins
5.	Defensins
6.	Vitellogenins (Vitellogenin)
7.	RNA (Ribonucleic Acid)
8.	Cathepsin B
9.	Adenosine Monophosphate (AMP)