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glycyl- arginyl- glycyl- aspartyl- seryl- proline

can duplicate the binding activity of fibronectin vitronectin; RN given refers to ALL-L isomer
Also Known As:
GRGDSP; GdRGDSP; Gly-Arg-Gly-Asp-Ser-Pro; glycyl-arginyl-glycyl-aspartyl-seryl-proline, D-seryl isomer
Networked: 25 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Qian, Jun: 3 articles (06/2016 - 04/2006)
2. Wang, Yong: 2 articles (03/2008 - 04/2006)
3. Yin, Jun: 2 articles (03/2008 - 04/2006)
4. Imlau, Ulli: 1 article (06/2016)
5. Oppermann, Elsie: 1 article (06/2016)
6. Qian, Kun: 1 article (06/2016)
7. Tran, Andreas: 1 article (06/2016)
8. Vogl, Thomas Josef: 1 article (06/2016)
9. Belkin, A M: 1 article (12/2014)
10. Medved, L: 1 article (12/2014)

Related Diseases

1. Carcinoma (Carcinomatosis)
2. Neoplasms (Cancer)
08/01/1997 - "Binding of tumor cells to surface-immobilized gamma1(RGD)3 was inhibited in a dose-dependent manner by the RGD-containing synthetic peptides GdRGDSP and RGDS. "
11/01/1988 - "Interaction of melanoma cells with subendothelial matrix did not appear to play a primary role because: 1) phase contrast and electron microscopy revealed direct contact between tumor cells and endothelial cells in standardized monolayer adhesion assays; 2) increased adhesion (rosette formation) of tumor cells to activated HEC was also observed after nonenzymatic resuspension of HEC, and 3) the matrix peptide GRGDSP partially blocked (approximately 45%) Hs 294T cell adhesion to subendothelial matrix, but had little or no effect on adhesion to activated HEC monolayers. "
06/07/2016 - "To compare the effect of transarterial chemoembolization (TACE) plus GRGDSP (Gly-Arg-Gly-Asp-Ser-Pro, integrin-inhibitor) loaded nanoparticles with TACE alone or TACE + GRGDSP in a rat model of liver tumor. "
10/01/2011 - "In addition, the use of curcumin, an anti-cancer drug, or GRGDSP, the blocking peptide along with exogenous HABP1, inhibited such NFκB-dependent pathway, confirming that HABP1-induced cell migration is α(v)β(3) integrin-mediated and downstream signaling by NFκB. "
06/07/2016 - "Tumor volume before treatment (V1) was examined by magnetic resonance imaging (MRI), and then, after laparotomy and placement of a PE-10 catheter into the hepatic artery, the following interventional protocols were performed: TACE (mitomycin C + lipiodol + degradable starch microspheres) + GRGDSP loaded nanoparticles for group A; TACE + GRGDSP for group B (control group 1); TACE alone for group C (control group 2). "
3. Melanoma (Melanoma, Malignant)
4. Osteosarcoma (Osteogenic Sarcoma)
5. Neoplasm Metastasis (Metastasis)

Related Drugs and Biologics

1. Peptides (Polypeptides)
2. Collagen Type IV (Type IV Collagen)
3. Serine (L-Serine)
4. Collagen
5. arginyl-glycyl-aspartic acid
6. Integrins
7. glycyl- arginyl- glycyl- aspartyl- seryl- proline
8. Fibronectins (Fibronectin)
9. Integrin alphaVbeta3
10. Proteins (Proteins, Gene)

Related Therapies and Procedures

1. Catheters
2. Laparotomy