L 365260

a CCK-B antagonist; structure given in first source; potent & selective CCK-B & gastrin receptor ligand; L 365260 and L 365346 are (R)- and (S)-stereoisomers, respectively

Also Known As:

L 365,260; L 365346; L-365260

Networked: 6 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzazepines: 5
      - Benzodiazepines: 8452
        Benzodiazepinones
        L 365260: 6
Organic Chemicals: 133
- Amides: 2428
  - Urea: 15015
    - Phenylurea Compounds: 1
      - L 365260: 6
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenylurea Compounds: 1
        L 365260: 6

Related Diseases

1.	Colonic Neoplasms (Colon Cancer) 09/01/1996 - "This study defined the nature of gastrin binding in human colon cancer using [3H]L-365,260, a specific cholecystokinin B (CCK-B)/gastrin antagonist found to block gastrin's effects on growth. "
2.	Stomach Neoplasms (Stomach Cancer) 02/01/1998 - "By performing receptor binding assays on human AGS gastric cancer cells with the selective CCK-B/gastrin receptor antagonist [3H]L-365,260, specific and saturable binding were determined. "
3.	Seizures (Absence Seizure) 02/01/1995 - "We studied the effect of subcutaneous morphine and intracerebroventricularly administered cholecystokinin octapeptide sulphate ester and receptor antagonists CCK-A (MK 329) and CCK-B (L 365,260) on seizures provoked by maximal electroshock in male Sprague-Dawley rats. "
4.	Pancreatic Neoplasms (Pancreatic Cancer) 01/01/1994 - "Assays performed with [3H]L-365,260 on five additional human pancreatic cancer cell lines in vitro and tumor tissue from xenografts in nude mice also revealed specific and saturable binding. " 01/01/1994 - "With the use of homogenates of PANC-1 human pancreatic cancer cells grown in vitro, the binding characteristics and optimal conditions of radiolabeled selective CCK-receptor antagonists ([3H]L-365,260 and [3H]L-364,718) were examined. "
5.	Neoplasms (Cancer) 01/01/1994 - "Assays performed with [3H]L-365,260 on five additional human pancreatic cancer cell lines in vitro and tumor tissue from xenografts in nude mice also revealed specific and saturable binding. "

Related Drugs and Biologics

1.	Cholecystokinin (Pancreozymin)
2.	Gastrins
3.	Devazepide
4.	Cholecystokinin B Receptor
5.	Cholecystokinin Receptors (Cholecystokinin Receptor)
6.	Cholecystokinin A Receptor
7.	Sincalide
8.	Neurotensin
9.	Morphine (MS Contin)
10.	Esters