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zinc mesoporphyrin

inhibits bilirubin production in rats

Also Known As:

21H,23H-Porphine-2,18-dipropanoic acid, 7,12-diethyl-3,8,13,17-tetramethyl-, zinc salt (1:1); ZnMP

Networked: 8 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Bonkovsky, Herbert L: 2 articles (05/2010 - 03/2008)
2.	Hou, Weihong: 2 articles (05/2010 - 03/2008)
3.	Zheng, Jianyu: 2 articles (05/2010 - 03/2008)
4.	Tian, Qing: 1 article (05/2010)
5.	Donohue, Susan E: 1 article (03/2008)
6.	Lambrecht, Richard W: 1 article (03/2008)
7.	Shan, Ying: 1 article (03/2008)
8.	Hoffmann, F: 1 article (05/2001)
9.	Lindberg, R L: 1 article (05/2001)
10.	Meyer, U A: 1 article (05/2001)

Related Diseases

1.	Hepatic Porphyrias (Hepatic Porphyria) 05/01/2001 - "We conclude that the combined effect of ZnMP on highly induced ALAS and on HO may be of potential benefit for human acute hepatic porphyrias and therefore merits further in vivo investigations addressing questions raised by this study."
2.	Acute Intermittent Porphyria (Porphyria, Acute) 02/01/1995 - "Recent results from our laboratory showed that a combination of heme and zinc-mesoporphyrin was remarkably effective in ameliorating biochemical features of acute porphyria. " 06/01/1994 - "Repression of ALA synthase by heme and zinc-mesoporphyrin in a chick embryo liver cell culture model of acute porphyria." 08/01/1994 - "The ability of zinc-mesoporphyrin to supplement the reduction of delta-aminolevulinic acid synthase mRNA by heme, in a process similar to that observed with heme alone, provides a rationale for further investigation of this compound for eventual use as a supplement to heme therapy of the acute porphyrias and perhaps other conditions in which heme may be of benefit."
3.	Hepatocellular Carcinoma (Hepatoma) 05/01/2010 - "Human hepatoma cells expressing HCV proteins were used to investigate the posttranslational regulation of ZnMP on NS5A protein by Western blots and immunoprecipitation. " 05/01/2010 - "Zinc mesoporphyrin induces rapid proteasomal degradation of hepatitis C nonstructural 5A protein in human hepatoma cells." 03/01/2008 - "To understand how zinc mesoporphyrin (ZnMP) induces the expression of HO-1, we investigated the effects of ZnMP on Bach1 mRNA and protein levels in human hepatoma Huh-7 cells by quantitative RT-PCR and Western blots. "
4.	Massive Hepatic Necrosis 05/01/2010 - "In addition, 10 micromol/L of ZnMP reduced HCV replication by approximately 63% in the Con1 replicon cells, approximately 70% in J6/Japanese fulminant hepatitis 1 HCV-transfected cells, and approximately 90% in J6/Japanese fulminant hepatitis 1 HCV-infected cells without affecting cell viability. "
5.	Cutaneous Leishmaniasis 09/10/2022 - "Here, we characterized the kinetics of the uptake of the heme analogue Zn(II) Mesoporphyrin IX (ZnMP) in Leishmania major promastigotes as a model of a parasite causing cutaneous leishmaniasis with special focus on the force that drives the process. "

Related Drugs and Biologics

1.	Heme (Haem)
2.	Messenger RNA (mRNA)
3.	Proteins (Proteins, Gene)
4.	zinc mesoporphyrin
5.	Aminolevulinic Acid (Levulan)
6.	mesoporphyrin IX

Related Therapies and Procedures

1.	Therapeutics