meliacin

12/01/2009 - "These results indicate that meliacine could be an alternative therapeutic compound against HSV-2 genital infection."
04/01/1998 - "The addition of meliacine at different times after infection indicated that meliacine also interferes with the release of infectious particles to the extracellular medium and inhibits the low-pH-induced fusion of infected cells. "
04/01/1998 - "Analysis of early events following infection demonstrated that meliacine blocks virus penetration by preventing the uncoating step. "
08/01/2000 - "Infected animals treated or not with meliacine were observed carefully for the development of stromal keratitis and the clinical scoring was done 14 days post-infection. "
12/01/2009 - "The purpose of the present study was to evaluate the therapeutic effect of intravaginal administration of meliacine in a mouse model of genital herpetic infection. "

08/01/2000 - "Infected animals treated or not with meliacine were observed carefully for the development of stromal keratitis and the clinical scoring was done 14 days post-infection. "
11/01/2012 - "Meliacine (MA), an antiviral principle present in partially purified leaf extracts of Melia azedarach L., reduces viral load and abolishes the inflammatory reaction and neovascularization during the development of herpetic stromal keratitis in mice. "
04/01/2009 - "Meliacine (MA), an antiviral principle present in partially purified leaf extracts of Melia azedarach L., prevents the development of herpetic stromal keratitis (HSK) in mice by diminishing the viral load in the eye and the severity of lesions caused by a virus-induced immunopathological reaction. "
08/01/2000 - "Treatment with meliacine, a plant derived antiviral, prevents the development of herpetic stromal keratitis in mice."

07/01/1988 - "A partially purified plant inhibitor (Meliacin) isolated from Melia azedarach L induced in cells a refractory state to virus infection. "
06/13/2006 - "Since IFN response represents an early host defense event against viral infection and the fact that treatment with meliacine, a plant antiviral, ameliorate the severity of the herpetic infection in female mice infected intravaginally with HSV-2, we wanted to investigate whether the administration of meliacine to HSV-2 infected mice could altered the homoestasis of IFNs host response. "

01/01/1991 - "The berries of the tree contain cyclic terpens (Meliacine) well known for inducing inflammation by contact with the skin. "

01/01/1997 - "We evaluated the in vitro antiviral activity of meliacin combined with foscarnet on the herpes simplex type 1 (HSV-1) strains F and B2006 (tk-) replication. "