immunomycin (ascomycin)

from Streptomyces hygroscopicus; structure given in first source

Also Known As:

ascomycin; FK 520; FK-520; FR 900520; FR-900520; changchuanmycin; tacrolimus related compound A; 15,19-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl)-14,16-dimethoxy-4,10,12,18-tetram

Networked: 40 relevant articles (6 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Lactones: 1549
  - Macrolides: 4391
    - Tacrolimus: 7819
      - immunomycin: 40

Experts

1.	Stuetz, Anton: 3 articles (08/2007 - 03/2004)
2.	Sierra-Marcuño, Germán: 2 articles (01/2008 - 07/2006)
3.	Sierra-Paredes, Germán: 2 articles (01/2008 - 07/2006)
4.	Wolff, Klaus: 2 articles (01/2006 - 03/2004)
5.	Graeber, Michael: 2 articles (01/2003 - 04/2002)
6.	Jarvis, Blair: 2 articles (01/2002 - 01/2002)
7.	Wellington, Keri: 2 articles (01/2002 - 01/2002)
8.	Stuetz, A: 2 articles (12/2001 - 01/2000)
9.	Graeber, M: 2 articles (04/2001 - 01/2000)
10.	Paul, C: 2 articles (03/2001 - 01/2000)

Related Diseases

1.	Atopic Dermatitis (Atopic Eczema) 04/01/2001 - "Ascomycin: an advance in the management of atopic dermatitis." 03/01/2000 - "In particular, tacrolimus and ascomycin derivatives have been shown to be effective for treating atopic dermatitis with a surprising lack of side effects. " 01/01/2002 - "Pimecrolimus (SDZ ASM 981), an ascomycin derivative, is a nonsteroid, has anti-inflammatory activity, and has demonstrated efficacy in reducing symptoms of atopic dermatitis in adult and pediatric patients when applied topically. " 01/01/2002 - "Pimecrolimus (SDZ ASM 981), an ascomycin derivative, is a nonsteroid, has anti-inflammatory activity, and has demonstrated efficacy in reducing symptoms of atopic dermatitis in adult and paediatric patients when applied topically. " 08/01/2007 - "Pimecrolimus is an ascomycin macrolactam derivative that has been recently approved for the topical treatment of atopic dermatitis. "
2.	Psoriasis (Pustulosis Palmaris et Plantaris) 01/01/2003 - "Pimecrolimus (Elidel, SDZ ASM 981), a new macrolactam ascomycin derivative, was highly effective in treating plaque-type psoriasis when applied under Finn-chamber occlusion. " 12/01/1998 - "The novel ascomycin derivative SDZ ASM 981 is effective for psoriasis when used topically under occlusion." 11/01/1999 - "Pimecrolimus, an ascomycin macrolactam derivative, is an inhibitor of T-cell and mast cell activation under development by Novartis for the potential treatment of psoriasis and allergic dermatitis. " 03/01/2011 - "(iii) Tacrolimus and ascomycin help in treating inflammatory skin disease such as allergic contact dermatitis and psoriasis. " 08/01/1999 - "SDZ ASM 981, a novel ascomycin macrolactam derivative, has high anti-inflammatory activity in animal models of allergic contact dermatitis and shows clinical efficacy in atopic dermatitis, allergic contact dermatitis and psoriasis, after topical application. "
3.	Skin Diseases (Skin Disease) 04/01/2001 - "It is the first ascomycin macrolactam derivative under development for the treatment of inflammatory skin diseases. " 01/01/2000 - "Ascomycin derivatives represent a novel class of anti-inflammatory macrolactams currently under development for the treatment of skin diseases. " 12/01/1998 - "Ascomycin derivatives represent a novel class of anti-inflammatory macrolactams that are under development for the treatment of skin diseases. " 10/01/1998 - "Discovery of ascomycin analogs with potent topical but weak systemic activity for treatment of inflammatory skin diseases." 01/01/2005 - "Pimecrolimus (SDZ ASM 981), an ascomycin derivative, as one of the new classes of immunomodulating macrolactams, is specifically effective in the treatment of inflammatory skin diseases. "
4.	Seizures (Absence Seizure) 07/01/2006 - "Mean seizure duration and mean number of seizures were significantly reduced (P < 0.01) by microperfusion of 100 microM ascomycin. " 07/01/2006 - "Low concentrations (10 microM) of ascomycin did not prevent picrotoxin seizures, however, 50 and 100 microM ascomycin showed antiepileptic effect, completely suppressing seizures in 41.7% and 75% of the animals studied respectively. " 07/01/2006 - "The potential in vivo anticonvulsant effect of calcineurin (protein phosphatase 2B) inhibitor ascomycin against seizures induced by intrahippocampal microdialysis of picrotoxin was examined in the present study. " 07/01/2006 - "Anticonvulsant effect of the calcineurin inhibitor ascomycin on seizures induced by picrotoxin microperfusion in the rat hippocampus."
5.	Atrophy 03/01/2001 - "The new topical ascomycin derivative SDZ ASM 981 does not induce skin atrophy when applied to normal skin for 4 weeks: a randomized, double-blind controlled study."

Related Drugs and Biologics

1.	pimecrolimus (Elidel)
2.	Tacrolimus (Prograf)
3.	Immunosuppressive Agents (Immunosuppressants)
4.	Calcineurin
5.	Macrolides
6.	Therapeutic Uses
7.	Picrotoxin
8.	Anticonvulsants (Antiepileptic Drugs)
9.	Cytokines
10.	Cyclosporine (Ciclosporin)

Related Therapies and Procedures

1.	Therapeutics