homoorientin (isoorientin)

isolated from Swertia japonica; structure given in first source

Also Known As:

isoorientin; 6-Glc-luteolin; iso-orientin; luteolin-6-C-glucoside; 4H-1-benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-6-beta-D-glucopyranosyl-5,7-dihydroxy-

Networked: 54 relevant articles (5 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Flavones: 446
        Luteolin: 1323
        homoorientin: 54
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Flavones: 446
        Luteolin: 1323
        homoorientin: 54

Experts

1.	Yuan, Li: 7 articles (08/2021 - 11/2012)
2.	Liu, Xuebo: 5 articles (07/2016 - 11/2012)
3.	Wang, Jing: 5 articles (07/2016 - 11/2012)
4.	Li, Qing X: 4 articles (11/2022 - 01/2020)
5.	Dludla, Phiwayinkosi V: 4 articles (10/2021 - 01/2020)
6.	Kappo, Abidemi P: 4 articles (10/2021 - 01/2020)
7.	Mazibuko-Mbeje, Sithandiwe E: 4 articles (10/2021 - 01/2020)
8.	Muller, Christo J F: 4 articles (10/2021 - 01/2020)
9.	Tan, Xiaoqin: 3 articles (11/2022 - 01/2020)
10.	Louw, Johan: 3 articles (06/2020 - 01/2020)

Related Diseases

1.	Inflammation (Inflammations) 02/01/2022 - "Isoorientin (ISO) exerts a momentous role in the regulation of inflammation. " 01/01/2020 - "In summary, isoorientin can inhibit GSK3β by increasing p-GSK3β and regulate the downstream signal molecules to inhibit inflammation and protect the integrity of the blood-brain barrier and the homeostasis in the brain." 07/01/2014 - "Vascular barrier protective effects of orientin and isoorientin in LPS-induced inflammation in vitro and in vivo." 08/01/2022 - "A Pretreatment with Isoorientin Attenuates Redox Disruption, Mitochondrial Impairment, and Inflammation Caused by Chlorpyrifos in a Dopaminergic Cell Line: Involvement of the Nrf2/HO-1 Axis." 11/22/2021 - "Isoorientin Inhibits Amyloid β25-35-Induced Neuronal Inflammation in BV2 Cells by Blocking the NF-κB Signaling Pathway."
2.	Mitochondrial Diseases (Mitochondrial Disease) 11/15/2012 - "Isoorientin induces apoptosis through mitochondrial dysfunction and inhibition of PI3K/Akt signaling pathway in HepG2 cancer cells." 03/28/2018 - "Finally, isoorientin improved mitochondrial dysfunction induced by dexamethasone in 3T3-L1 adipocytes. " 02/01/2023 - "The C-glucosyl flavone isoorientin pretreatment attenuates the methylglyoxal-induced mitochondrial dysfunction in the human neuroblastoma SH-SY5Y cells: role for the AMPK-PI3K/Akt/Nrf2/γ-GCL/GSH axis." 10/18/2021 - "Rooibos Flavonoids, Aspalathin, Isoorientin, and Orientin Ameliorate Antimycin A-Induced Mitochondrial Dysfunction by Improving Mitochondrial Bioenergetics in Cultured Skeletal Muscle Cells." 10/18/2021 - "Overall, the current study showed that dietary flavonoids, aspalathin, isoorientin, and orientin, have the potential to be as effective as established pharmacological drugs such as metformin and insulin in protecting against mitochondrial dysfunction in a preclinical setting; however, such information should be confirmed in well-established in vivo disease models."
3.	Wounds and Injuries (Trauma) 12/01/2014 - "Isoorientin (10 µM) improved wound closure by 29 % (12 h) and 56 % (24 h), respectively. "
4.	Osteoporosis 12/01/2022 - "Isoorientin ameliorates osteoporosis via upregulating OPG and Nrf2/ARE signalling, suggesting isoorientin maybe a potential therapeutic drug for PMOP."
5.	Asthma (Bronchial Asthma) 01/01/2022 - "Isoorientin ameliorates OVA-induced asthma in a murine model of asthma."

Related Drugs and Biologics

1.	orientin
2.	Dexamethasone (Maxidex)
3.	Flavonoids
4.	Lipopolysaccharides
5.	Insulin (Novolin)
6.	Cyclooxygenase 2 (Cyclooxygenase-2)
7.	Metformin (Glucophage)
8.	Doxorubicin (Adriamycin)
9.	aspalathin
10.	Antioxidants

Related Therapies and Procedures

1.	Oral Administration