trimethylaminocarboxyldihydroboran (TCDB)

11/09/2022 - "difficile toxin gene, tcdB, using 2641 stool specimens collected from children enrolled in the Alberta Provincial Pediatric EnTeric Infection Team (APPETITE) study in Alberta, Canada. "
01/01/2018 - "Infection studies with isogenic strains having defined toxin deletions have established TcdB as an important target for therapeutic development. "
08/01/2023 - "Clostridioides difficile PCR Tcdb Cycle Threshold predicts toxin EIA positivity but not severity of infection."
01/12/2023 - "infection is derived from two major toxins, toxins A (TcdA) and B (TcdB). "
01/01/2023 - "Our results reveal Hsp70 requirement as a new aspect of the cellular uptake mechanism of TcdB and identified Hsp70 as a novel drug target for potential therapeutic strategies required to combat severe Clostridioides difficile infections."

01/01/2020 - "We conducted a small molecule screen to identify compounds that confer protection against TcdB-induced necrosis. "
04/12/2022 - "TcdB of Clostridioides difficile Mediates RAS-Dependent Necrosis in Epithelial Cells."
01/01/2020 - "Disruption of TcdB-induced calcium signaling (with both DHP and non-DHP molecules) is sufficient to ablate ROS production and prevent subsequent necrosis in cells and in a mouse model of intoxication."
01/01/2012 - "We conclude that autoprocessing and GTD release is not required for epithelial cell necrosis and that targeting the autoprocessing activity of TcdB for the development of novel therapeutics will not prevent the colonic tissue damage that occurs in C. "
01/11/2016 - "Disease is mediated by the actions of two toxins, TcdA and TcdB, which cause the diarrhoea, as well as inflammation and necrosis within the colon. "

01/01/2023 - "difficile) toxins A (TcdA) and B (TcdB) cause antibiotic-associated colitis in part by disrupting epithelial barrier function. "
04/13/2016 - "TcdB-together with Toxin A (TcdA)-is causative for the pseudomembranous colitis (PMC). "
01/01/2016 - "difficile secretes toxins A and B (TcdA and TcdB) and both toxins act synergistically to induce a spectrum of pathological responses in infected individuals ranging from pseudomembranous colitis to C. "
06/02/2015 - "The receptor is highly expressed on the surface epithelium of the human colon and was observed to colocalize with TcdB in both an explant model and in tissue from a patient with pseudomembranous colitis. "
03/01/2001 - "difficile, TcdA-10463 (TcdA) and TcdB-10463 (TcdB), and a model intestinal epithelial cell line to characterize their influence on tight-junction (TJ) organization and hence to analyze the mechanisms by which they contribute to the enhanced paracellular permeability and disease pathophysiology of pseudomembranous colitis. "

08/08/2019 - "Moreover, DABMA exhibited enhanced efficacy against Clostridium difficile toxin B (TcdB), Clostridium sordellii lethal toxin (TcsL), Pseudomonas Exotoxin A (PE) as well as Rabies and Ebola viruses. "

08/01/2008 - "The introduction of internal benchmarking (TCDB and core measures) was associated with some changes, at least in some diagnostic domains, which may lead to improvement in QOC for lung cancer in Taiwan."
08/01/2008 - "Based on core measures in the Taiwan Cancer Database (TCDB) registry, QOC for lung cancer was measured as variation in POC for 16 selected core measures for different hospital characteristics. "