Aprotinin FDA Link

A single-chain polypeptide derived from bovine tissues consisting of 58 amino-acid residues. It is an inhibitor of proteolytic enzymes including CHYMOTRYPSIN; KALLIKREIN; PLASMIN; and TRYPSIN. It is used in the treatment of HEMORRHAGE associated with raised plasma concentrations of plasmin. It is also used to reduce blood loss and transfusion requirements in patients at high risk of major blood loss during and following open heart surgery with EXTRACORPOREAL CIRCULATION. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)

Also Known As:

Trasylol; Antilysin; Bovine Pancreatic Trypsin Inhibitor; Contrical; Contrykal; Dilmintal; Iniprol; Kontrikal; Kontrykal; Pulmin; Traskolan; Zymofren; Inactivator, Kallikrein-Trypsin; Kallikrein Trypsin Inactivator; BPTI, Basic Pancreatic Trypsin Inhibitor; Basic Pancreatic Trypsin Inhibitor; Bovine Kunitz Pancreatic Trypsin Inhibitor; Kallikrein-Trypsin Inactivator; Kunitz Pancreatic Trypsin Inhibitor; Trypsin Inhibitor, Basic, Pancreatic; Trypsin Inhibitor, Kunitz, Pancreatic

Pharmalogical Action Categories:

Hemostatics
Serine Proteinase Inhibitors
Trypsin Inhibitors

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Aprotinin: 1522

Arg(15)-Glu(52)- aprotinin

Bio-Agent Context: Research Results