apigetrin

structure given in first source

Also Known As:

apigenin 7-O-beta-glucoside; apigenin-7-D-glucoside; apigenin-7-O-beta-D-glucopyranoside; apigenin-7-glucoside; cosmetin; cosmosiin; 4H-1-Benzopyran-4-one, 7-(b-D-glucopyranosyloxy)-5-hydroxy-2-(4-hydroxyphenyl)-

Networked: 19 relevant articles (2 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Flavones: 446
        Apigenin: 1098
        apigetrin: 19
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Flavones: 446
        Apigenin: 1098
        apigetrin: 19

Experts

1.	Kim, Jin-A: 2 articles (06/2022 - 01/2020)
2.	Han, Hengmin: 1 article (06/2022)
3.	Kim, Jung-Eun: 1 article (06/2022)
4.	Lee, Hyo-Jeong: 1 article (06/2022)
5.	Lee, Jae-Hyeon: 1 article (06/2022)
6.	Lee, You-Kyung: 1 article (06/2022)
7.	Xu, Yinzhu: 1 article (06/2022)
8.	Abusaliya, Abuyaseer: 1 article (06/2022)
9.	Bhagwan Bhosale, Pritam: 1 article (06/2022)
10.	Ha, Sang-Eun: 1 article (06/2022)

Related Diseases

1.	Diabetes Complications 01/01/2011 - "These findings indicate that rhoifolin and cosmosiin from red wendun leaves may be beneficial for diabetic complications through their enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and GLUT4 translocation."
2.	Cytokine Release Syndrome 11/01/2023 - "Apigetrin significantly improved IAV-induced oxidative stress, inhibited the IAV-induced cytokine storm by suppressing the excessive activation of TLR3/4/7, JNK/p38 MAPK and NF-κB. "
3.	Neoplasms (Cancer) 06/09/2022 - "Silencing of AKT revealed that the anti-cancer activity of apigetrin is mediated via AKT. " 05/01/2011 - "This is the first evidence that natural compound apigetrin may induce cancer cell differentiation thus could be one of the possible explanations of its antitumor effects." 06/09/2022 - "In the present study, we elucidated the anti-cancer effect and targeting mechanism of apigetrin in LNCaP and PC-3 cells through various experiments, including cell viability by CELLOMAXTM Viability Assay kit, cell migration by scratch wound assays, and 2D-and 3D- cell growth assay. " 06/09/2022 - "Thus, our data suggest that apigetrin exerts anti-cancer effects by inhibiting AKT, a central key of HIF-1α and AR signaling, in early-and late-stage prostate cancer cells." 06/09/2022 - "AKT, a Key Transmitter of HIF-1α and AR Signaling Pathways, Has a Critical Role in the Apigetrin-Mediated Anti-Cancer Effects in Prostate Cancer Cells."
4.	Inflammation (Inflammations) 06/01/2023 - "Consequently, we provide in silico insights into the potential of apigetrin to target AChE/COX-2/NOX/NF-κB Altogether the present study provides preclinical evidence of the therapeutic potential of the apigetrin-enriched PAm extract for treating oxidative stress and neuro-inflammation associated with diabetes." 06/01/2023 - "Apigetrin-enriched Pulmeria alba extract prevents assault of STZ on pancreatic β-cells and neuronal oxidative stress with concomitant attenuation of tissue damage and suppression of inflammation in the brain of diabetic rats." 01/01/2019 - "Apigetrin treatment attenuates LPS-induced acute otitis media though suppressing inflammation and oxidative stress." 06/08/2022 - "Apigetrin Abrogates Lipopolysaccharide-Induced Inflammation in L6 Skeletal Muscle Cells through NF-κB/MAPK Signaling Pathways." 03/01/1993 - "Subsequent intradermal application of liposomal apigenin-7-glucoside inhibited in a dose dependent manner skin inflammation caused by xanthine-oxidase and cumene hydroperoxide. "
5.	Stomach Neoplasms (Stomach Cancer) 01/01/2020 - "In the current study, we determined the effect of apigetrin on AGS gastric cancer cell. " 01/01/2020 - "Thus, our findings strongly indicate that apigetrin is a basic natural derived compound that could be used as a nutrient source with potential anticancer activities against gastric cancer." 01/01/2020 - "Taken together, these data suggest that apigetrin-treated AGS cells induced G2/M phase cell cycle arrest, extrinsic apoptosis and autophagic cell death through PI3K/AKT/mTOR pathway, which can lead to the inhibition of gastric cancer development. " 01/01/2020 - "Apigetrin induces extrinsic apoptosis, autophagy and G2/M phase cell cycle arrest through PI3K/AKT/mTOR pathway in AGS human gastric cancer cell." 01/01/2018 - "Apigetrin inhibits gastric cancer progression through inducing apoptosis and regulating ROS-modulated STAT3/JAK2 pathway."

Related Drugs and Biologics

1.	rhoifolin
2.	Adiponectin
3.	p38 Mitogen-Activated Protein Kinases
4.	Tyrosine (L-Tyrosine)
5.	Insulin Receptor
6.	Flavonoids
7.	Glucosides
8.	scolymoside
9.	luteolin-7-glucoside
10.	genkwanin