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hepatitis B virus X protein

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hepatitis B virus-encoded X (HBx) protein coactivates transcription of a variety of viral and cellular genes and it is believed to play essential roles in viral replication and hepatocarcinogenesis

Also Known As:

HBV X protein; HBx protein, Hepatitis B virus; HBxAg, HBV; X protein, hepatitis B virus; hepatitis B virus X antigen; pX protein, Hepatitis B virus; protein X, Hepatitis B virus; transcriptional transactivator hbx, HBV; viral X protein, Hepatitis B virus

Networked: 276 relevant articles (1 outcomes, 15 trials/studies)

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Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489

Experts

1.	Zhang, Xiaodong: 17 articles (03/2014 - 02/2005)
2.	Ye, Lihong: 17 articles (03/2014 - 02/2005)
3.	You, Xiaona: 9 articles (02/2014 - 05/2010)
4.	Zhang, Shuai: 9 articles (11/2013 - 01/2009)
5.	Cho, Hyeseong: 8 articles (12/2014 - 09/2002)
6.	Yu, Dae-Yeul: 8 articles (01/2014 - 09/2002)
7.	Sun, Qian: 6 articles (10/2014 - 12/2010)
8.	Cheng, Bin: 6 articles (10/2014 - 12/2010)
9.	Du, Yumei: 6 articles (11/2013 - 08/2011)
10.	Shan, Changliang: 6 articles (03/2013 - 05/2010)

Related Diseases

1.	Hepatocellular Carcinoma (Hepatoma) 01/01/2008 - "The aim of this study is to investigate the molecular mechanism of hepatocellular carcinoma (HCC) development induced by hepatitis B virus X protein (HBx). " 11/01/2002 - "Despite the extensive studies on the roles of hepatitis B virus (HBV) X protein (HBx) in the development of hepatocellular carcinomas (HCCs), the mechanisms by which HBx contributes to HCC remain controversial. " 11/02/2000 - "The aim of this study was to investigate whether there was a particular hepatitis B virus (HBV) X protein (HBx) mutant associated with Taiwanese patients with hepatocellular carcinoma (HCC). " 01/01/2016 - "Hepatitis B virus X protein activates Notch signaling by its effects on Notch1 and Notch4 in human hepatocellular carcinoma." 10/20/2015 - "Accumulating evidence supports an important role for the hepatitis B virus x protein (HBx) in the pathogenesis of hepatitis B virus (HBV)-induced hepatocellular carcinoma (HCC), but the underlying mechanisms are not entirely clear. "
2.	Infection 04/01/2012 - "The study on the role of hepatitis B virus X protein and apoptosis in HBV intrauterine infection." 06/20/2014 - "Functional interplay between hepatitis B virus X protein and human miR-125a in HBV infection." 02/01/2014 - "Chronic infection with hepatitis B virus (HBV) is the major risk factor for the development of HCC, while hepatitis B virus X protein (HBx) is essential for HBV-associated HCC. " 11/01/2011 - "Hepatitis B virus X protein is essential to initiate and maintain virus replication after infection." 01/01/2010 - "Here we report the crystal structure of DDB1 in complex with a central fragment of hepatitis B virus X protein (HBx), whose DDB1-binding activity is important for viral infection. "
3.	Neoplasms (Cancer) 09/01/2012 - "Our previous studies have demonstrated that hepatitis B virus X protein (HBx) was able to inhibit the growth of HCC cells via inducing apoptosis and inhibiting tumor angiogenesis. " 12/15/1995 - "Recent studies on a transgenic mouse tumor model suggest that HBV X protein may contribute to transformation by binding to and inactivating the cellular growth suppressor protein p53. " 10/23/2014 - "Remarkably, HBV X protein (HBx) expression significantly promotes the formation and malignant progression of Kras(G12D)-driven HCC as shown with the accelerated tumor onset, the increased tumor burden and the more poorly differentiated lesions. " 11/01/2013 - "Hepatitis B virus X protein inhibits tumor suppressor miR-205 through inducing hypermethylation of miR-205 promoter to enhance carcinogenesis." 03/01/2012 - "Finally, the viability of cancer cells transfected with a plasmid containing HBx (hepatitis B virus X protein) following treatment with TRAIL was also measured. "
4.	Inflammation 05/01/2014 - "We previously reported that HBV X protein (HBx) induces hepatic lipid accumulation and inflammation. " 09/01/2011 - "Hepatitis B virus (HBV) X protein (HBx) is a 17-kDa transcriptional coactivator that plays a significant role in the regulation of genes involved in inflammation and cell survival. " 01/01/2007 - "This effect of HBV does not involve chronic liver inflammation, is apparently due to enhanced hepatocellular apoptosis and compensatory regeneration following DEN treatment, and does not require the HBV X protein. " 11/01/2003 - "Hepatitis B virus X protein (HBx) is a transcriptional coactivator that plays a significant role in the regulation of genes involved in inflammation and cell survival. " 09/01/2000 - "HBV may cause HCC either directly via the HBV X protein, or indirectly by causing liver inflammation and cirrhosis. "
5.	Melanoma (Melanoma, Malignant) 12/16/2011 - "In this study, we found that the expression of the newly identified gene melanoma inhibitory activity 2 (MIA2) was reduced by HBV infection in vitro and in vivo, and that HBV X protein (HBx) plays a major role in this regulation. " 04/26/2012 - "A novel recombinant LM-based vaccine (Lmdd (LM ΔdalΔdat)-MPFG (multiple peptide fusing genes)) was developed with the ability to express and secrete hepatocellular carcinoma (HCC)-related tumor-associated antigens fragments due to the insertion of hepatitis B virus (HBV)-X protein (HBx)-derived epitopes HBx(52-60) and HBx(140-148), the universal T-helper epitope, alpha-fetoprotein (AFP) epitope AFP(158-166), and melanoma antigen gene (MAGE)-3(271-279) into the HBV core protein. "

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