cirsilineol

08/01/2021 - "The results of our study prove that cirsilineol effectively inhibits inflammation in both in vivo and in vitro conditions. "
08/01/2021 - "Reverse-transcription polymerase chain reaction (RT-PCR) analysis was done to analyze the gene expression of inflammatory markers in LPS-treated RAW 264.7 macrophages to prove that cirsilineol effectively inhibits inflammation in vitro. "
08/01/2021 - "Cirsilineol attenuates LPS-induced inflammation in both in vivo and in vitro models via inhibiting TLR-4/NFkB/IKK signaling pathway."
01/01/2023 - "The biological importance of cirsilineol against allergic rhinitis, inflammation, coronavirus, immune system, renal cellular membrane and protein glycation has also been discussed in the present work. "
05/10/2023 - "Protective Effects of Cirsilineol against Lipopolysaccharide-Induced Inflammation; Insights into HO-1, COX-2, and iNOS Modulation."

08/01/2021 - "The lung histopathological studies authentically confirm that cirsilineol potentially prevented the mice from LPS-induced lung inflammation."
08/01/2021 - "We estimated the myeloperoxidase activity and levels of cytokines, chemokines, and inflammatory markers to analyze the efficacy of cirsilineol against lipopolysaccharide (LPS)-induced lung inflammation. "

11/01/2008 - "In this study, we aimed at examining the anti-proliferative activity of cirsilineol against multiple types of cancer cells and the underlying mechanisms. "
01/01/2022 - "The results showed that cirsilineol suppressed the proliferation of DU-145 cancer cells in a dose-dependent manner with minimal cytotoxic effects against the normal cells. "
01/01/2022 - "Cirsilineol has been reported to exhibit anticancer effects against several human cancer cell lines. "
09/01/2020 - "Altogether, these findings provide evidence that cirsilineol inhibited the proliferation of NCIH-520 cells by inducing ROS-mediated apoptosis and offer new insight into the anti-proliferative potential of cirsilineol, which can further be exploited to either synthesise new derivatives or its candid usage as a herbal lead for cancer treatment."
11/01/2008 - "These results suggested that the induction of apoptosis via the mitochondrial pathway was involved in the anti-proliferative activity of cirsilineol against cancer cells."

09/01/2021 - "These results ultimately suggest that cirsilineol has gastroprotective effects that prevent the development of gastric ulcer."
09/01/2021 - "This study was designed to evaluate the gastroprotective activity of cirsilineol in hydrochloric acid (HCl)/ethanol-induced gastric ulcer model. "
09/01/2021 - "Gastroprotective effect of cirsilineol against hydrochloric acid/ethanol-induced gastric ulcer in rats."

01/01/2022 - "The present study was designed to evaluate the anticancer effects of cirsilineol against the human DU-145 prostate cancer cells. "
01/01/2022 - "Wound healing and Transwell assays showed that cirsilineol inhibits migration and invasion of DU-145 prostate cancer cells. "
01/01/2022 - "The western blot analysis showed that cirsilineol suppressed the expression of Bax and upregulated the expression of Bcl-2 in prostate cancer DU-145 cells. "
01/01/2022 - "The IC50 of cirsilineol was found to be 7 μM and 110 μM against prostate cancer DU-145 and normal HPrEC prostate cells, respectively. "
01/01/2022 - "Summing up, the results suggest that cirsilineol suppresses the proliferation of prostate cancer cells and may prove to be a beneficial lead molecule for the development of chemotherapy for prostate cancer."