jasplakinolide

01/01/1998 - "Jasplakinolide was also effective against the systemic Lewis lung carcinoma, decreasing lung metastases. "
01/01/1998 - "The response of human PC-3 and DU-145 prostate carcinoma cells and DU-145 xenografts and the response of the Lewis lung carcinoma to jasplakinolide were studied. "
01/01/1998 - "Jasplakinolide was a radiation sensitizer in the Lewis lung carcinoma. "
01/01/1998 - "Jasplakinolide: interaction with radiation and hyperthermia in human prostate carcinoma and Lewis lung carcinoma."
01/01/1998 - "In vivo, jasplakinolide was an active antitumor agent against the Lewis lung carcinoma and the DU-145 prostate carcinoma xenograft. "

09/01/2010 - "Therefore, we investigated whether pharmacological manipulation of actin polymerization modulates pathogenic effects of PV-IgG. Pharmacological stabilization of actin filaments via jasplakinolide significantly blocked cell dissociation and Dsg3 fragmentation, whereas cytochalasin D-induced actin depolymerization strongly enhanced pathogenic effects of PV-IgG. To substantiate these findings, we studied whether the protective effects of Rho GTPases, which are potent regulators of the actin cytoskeleton and were shown to be involved in pemphigus pathogenesis, were dependent on modulation of actin dynamics. "

01/01/1998 - "Jasplakinolide was also effective against the systemic Lewis lung carcinoma, decreasing lung metastases. "
01/01/1998 - "Lung metastases were further decreased when jasplakinolide was administered along with radiation to the subcutaneous primary tumor. "

01/01/2019 - "Hypoxia and LatA could cause a significant reduction in the ratio of F-actin/G-actin content, whereas jasplakinolide caused a significant increase in the ratio of F-actin/G-actin content. "
01/01/2019 - "Through the establishment of an in vitro cultured intestinal epithelial cell monolayer model (Caco-2), we treated cells with hypoxia or drugs [jasplakinolide or latrunculin A (LatA)] to detect changes in the transepithelial electrical resistance (TER), the expression of the cellular tight junction (TJ) proteins zonula occludens-1 (ZO-1) and occludin, the distribution of F-actin, the ratio of F-actin/G-actin content, and the expression of the cofilin protein. "

01/01/2018 - "Furthermore, jasplakinolide treatment of either tumor cells or brain slice significantly reduced tumor cell invasion. "
01/01/1998 - "In the DU-145 tumor, the effects of jasplakinolide and fractionated radiation for 1 or 2 weeks appeared to be primarily additive. "
08/01/2018 - "Notably, Rg3 also induced actin disruption in hepatoma cell line, HepG2, which was reversed by jasplakinolide, confirming that the anti-cancer effects of Rg3 shares the mechanism at least in part. "
01/01/1998 - "Lung metastases were further decreased when jasplakinolide was administered along with radiation to the subcutaneous primary tumor. "
11/01/2014 - "Therefore, the present study sought to determine the tolerated in vivo doses of cytochalasins and jasplakinolide in zebrafish (Danio rerio), a well-studied fish cancer model that is 1.5% the size of mice. "