erythromycin propionate-N-acetylcysteinate

12/18/2019 - "We established OVA-sensitized and -challenged acute and chronic asthma mice models to explore the expression of Epac at first. "
04/01/2009 - "Additionally, these children were 48% less likely (p = 0.042) to experience an episode of poor asthma control (EPAC). "
10/01/2011 - "Epac and PKA maintain a normally contractile ASM phenotype in a mitogenic environment, suggesting that specific activators of Epac and PKA may be beneficial in the treatment of airway remodelling in asthma."
12/11/2012 - "[Effects of H2 relaxin on the expression of Epac in a murine model of chronic asthma]."
12/11/2012 - "Relaxin alleviates the airway inflammation and airway smooth muscle cell proliferation in a murine model of chronic asthma probably through activating Epac and inhibiting the phosphorylation of ERK1/2."

01/01/2009 - "This review will focus on recent pharmacological and biochemical studies aiming at understanding the role of Epac in cardiomyocyte signaling and hypertrophy."
05/01/2013 - "Epac activation for several hours, even before the cell hypertrophies, induces a profound modulation of the excitation-contraction coupling: increasing the [Ca(2+)]i transient amplitude and cellular contraction. "
05/01/2013 - "In fact, it has been shown that Epac induces cardiomyocyte hypertrophy. "
09/01/2007 - "Developmental changes in gene expression of Epac and its upregulation in myocardial hypertrophy."
12/09/2005 - "Rac is involved in Epac-induced NFAT dependent cardiomyocyte hypertrophy. "

03/01/2022 - "These findings indicate that Epac activation via 8-O-cAMP ameliorates tubulointerstitial inflammation in DN through the C/EBP-β/SOCS3/STAT3 pathway."
01/01/2021 - "In a recent study, we demonstrated that EPAC, but not PKA, is a promising therapeutic target to regulate respiratory syncytial virus (RSV) replication and its associated inflammation. "
03/01/2022 - "However, the role of Epac in TEC-mediated tubulointerstitial inflammation in DN remains unknown. "
11/01/2021 - "To assess whether EPAC could regulate vWF release during inflammation, we utilized our EPAC1-null mouse model and revealed increased secretion of vWF in endotoxemic mice in the absence of the EPAC1 gene. "
09/04/2020 - "PI3K/eNOS pathway-mediated, inflammation-triggered vWF secretion is the target of the pharmacological manipulation of the cAMP-EPAC system."

01/01/2023 - "Activation of β-Adrenoceptors Promotes Lipid Droplet Accumulation in MCF-7 Breast Cancer Cells via cAMP/PKA/EPAC Pathways."
12/01/2012 - "The present study confirms initial evidence for the efficacy of cAMP elevation against oncogenic effects of leptin, identifies β3 integrin subunit and FAK as proteins strongly down-regulated by cAMP elevation, and suggests that both cAMP/PKA- and cAMP/Epac-dependent pathways are involved in inhibition of leptin-induced migration of MDA-MB-231 breast cancer cells. "
01/01/2017 - "EPAC is a substrate for efflux transporters P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP), but it is not a substrate for hepatic uptake transporters [organic anion transporting polypeptides OATP1B1 and OATP1B3]. "

10/01/2011 - "Epac and PKA maintain a normally contractile ASM phenotype in a mitogenic environment, suggesting that specific activators of Epac and PKA may be beneficial in the treatment of airway remodelling in asthma."
12/18/2019 - "Our results suggest that Epac has a protecting effect on asthmatic airway inflammation and airway remodeling, and Epac reduces ASMCs proliferation by inhibiting SOCE in part."
12/18/2019 - "The role of Epac in asthmatic airway inflammation and airway remodeling is unclear. "
12/18/2019 - "Exchange protein directly activated by cAMP (Epac) protects against airway inflammation and airway remodeling in asthmatic mice."
12/11/2012 - "To explore the effects of H(2) relaxin on the expression of exchange protein directly activated by cyclic adenosine monophosphate (Epac) in a murine model of chronic asthma and the roles in the management of airway remodelling. "