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5-methylurapidil

Also Known As:

5-methyl-urapidil

Networked: 10 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperazines: 26
    - 5-methylurapidil: 10

Experts

1.	Koss, Michael C: 2 articles (06/2003 - 02/2002)
2.	Yu, Yongxin: 2 articles (06/2003 - 02/2002)
3.	Gursoy, Erdal: 1 article (02/2002)
4.	Kukreja, Rakesh C: 1 article (02/2002)
5.	Tejero-Taldo, M Isabel: 1 article (02/2002)
6.	Zhao, Ting Cun: 1 article (02/2002)

Related Diseases

1.	Heart Failure 12/27/1996 - "This study examines whether the alpha 1-adrenoceptors in canine endothelium-denuded dorsal pedal artery and endothelium-denuded saphenous vein can be differentiated by 5-methyl-urapidil before (non-paced) and at end-stage heart failure induced by rapid ventricular pacing. " 12/27/1996 - "Interaction of 5-methyl-urapidil with alpha 1-adrenoceptors in canine blood vessels: impact of pacing-induced heart failure." 12/27/1996 - "At end-stage heart failure, 5-methyl-urapidil was a competitive antagonist against noradrenaline in both the artery and the vein with pA2 values of 8.1 (7.9-8.4) and 8.6 (8.2-9.1), respectively. " 12/27/1996 - "In contrast to noradrenaline, at end-stage heart failure, no antagonism was seen with the concentrations of 5-methyl-urapidil tested against phenylephrine. "
2.	Mydriasis 06/01/2003 - "In addition, the selective alpha(1A)-adrenoceptor antagonist, 5-methylurapidil (0.1-1 mg/kg, i.v.), antagonized the elicited mydriasis in a dose-dependent fashion. " 02/01/2002 - "Evoked mydriasis was significantly antagonized by both WB-4101 and 5-methylurapidil but not by BMY-7378. "
3.	Infarction (Infarctions) 02/01/2002 - "Chloroethylclonidine blocked the effect of phenylephrine (infarct size 31.31 +/- 1.69%) but 5-methyl-urapidil (17.72 +/- 1.25%) did not. " 10/01/1997 - "Thus we examined in rabbits whether the alpha1b-adrenoceptor blocker chloroethylclonidine (CEC), the alpha1a-adrenoceptor blocker 5-methylurapidil (5-MU), the selective alpha1-adrenoceptor antagonist bunazosin (BN), and the nonselective apha-adrenoceptor antagonist phenoxybenzamine (POB) can block the PC effect on infarct size. "
4.	Stroke (Strokes) 12/29/1995 - "Phenylephrine infusion in the stroke-prone spontaneously hypertensive rats caused changes in renal haemodynamics and fluid excretion of comparable magnitude to that achieved in Wistars which was blocked by 5-methylurapidil but not chloroethylclonidine. "
5.	Tachycardia (Tachyarrhythmias) 01/01/1993 - "5-methyl-urapidil induced a significant tachycardia in WKY, but had little effect on heart rate in SHR. "

Related Drugs and Biologics

1.	chlorethylclonidine
2.	Phenylephrine (Neo-Synephrine)
3.	Phenoxybenzamine
4.	5-HT1A Serotonin Receptor
5.	Yohimbine (Yocon)
6.	Veratrine
7.	Thyroxine (Levothyroxine)
8.	Adrenergic Receptors (Adrenergic Receptor)
9.	Phentolamine (Z-Max)
10.	Norepinephrine (Noradrenaline)

Related Therapies and Procedures

1.	Therapeutics